HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33731348, 21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 765
+	Hs
		377055 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TOP1_HUMAN (1-765): 0: 932: 100.00
+	Hs
		369815 ESR1_HUMAN (1-595): 0: 599: 100.00		NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92
+	Hs
		1154059 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92
+	Hs
		782571 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92
+	Hs
		377401 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92
+	Hs
		487522 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92