Protein: SYMC
Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)

Gene: SYMC, MES1
Organism: Saccharomyces cerevisiae S288C
Interactions: 97
UniProt ID: P00958

Gene Ontology (top 5):
GO:0004825 - methionine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006424 - glutamyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

368908

ARC1
tRNA-aminoacylation cofactor ARC1

12

11

Small-scale

0.981

High

368907

SYEC
Glutamate--tRNA ligase, cytoplasmic

5

9

Small-scale

0.712

High

368838

SYMC
Methionine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.665

High

368872

SYLC
Leucine--tRNA ligase, cytoplasmic

1

15

High-throughput

0.618

High

368862

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.611

High

368912

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

2

1

High-throughput

0.588

High

368906

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

368840

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.571

High

368864

HSC82
ATP-dependent molecular chaperone HSC82

2

8

High-throughput

0.571

High

368870

SIS1
Protein SIS1

2

6

High-throughput

0.571

High

368902

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

368860

HSP71
Heat shock protein SSA1

1

13

High-throughput

0.536

High

368919

IMA1
Importin subunit alpha

1

2

High-throughput

0.536

High

368868

DBF2
Cell cycle protein kinase DBF2

1

6

High-throughput

0.501

High

368874

KCC1
Calcium/calmodulin-dependent protein kinase I

1

3

High-throughput

0.501

High

368900

KC13
Casein kinase I homolog 3

1

3

High-throughput

0.501

High

368875

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.493

High

149448

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

368842

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

368843

SYTC
Threonine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.479

High

368844

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

15

High-throughput

0.479

High

368845

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

368846

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

368847

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

368848

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

368851

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

368852

PBS2
MAP kinase kinase PBS2

1

4

High-throughput

0.479

High

368854

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.479

High

368856

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.479

High

368858

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

368865

SYKC
Lysine--tRNA ligase, cytoplasmic

1

15

High-throughput

0.479

High

368869

KCC2
Calcium/calmodulin-dependent protein kinase II

1

4

High-throughput

0.479

High

368877

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

368878

HS104
Heat shock protein 104

1

6

High-throughput

0.479

High

368879

HOG1
Mitogen-activated protein kinase HOG1

1

6

High-throughput

0.479

High

368880

ZUO1
Zuotin

1

7

High-throughput

0.479

High

368883

RSSA1
Small ribosomal subunit protein uS2A

1

6

High-throughput

0.479

High

368884

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

368886

PRS6A
26S proteasome regulatory subunit 6A

1

8

High-throughput

0.479

High

368888

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

368889

GBLP
Small ribosomal subunit protein RACK1

1

10

High-throughput

0.479

High

368890

SYG
Glycine--tRNA ligase 1, mitochondrial

1

13

High-throughput

0.479

High

368892

ATG8
Autophagy-related protein 8

1

7

High-throughput

0.479

High

368893

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

368894

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

15

High-throughput

0.479

High

368895

YHI0
Putative proline--tRNA ligase YHR020W

1

11

High-throughput

0.479

High

368898

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.479

High

368899

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

368911

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

368915

SYC
Cysteine--tRNA ligase

1

9

High-throughput

0.479

High

368917

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

368920

ESP1
Separin

1

1

High-throughput

0.479

High

368921

TOM1
E3 ubiquitin-protein ligase TOM1

1

9

High-throughput

0.479

High

368927

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

368930

DBP10
ATP-dependent RNA helicase DBP10

1

7

High-throughput

0.479

High

368932

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

368931

GDIR
Rho GDP-dissociation inhibitor

1

0

High-throughput

0.460

High

368839

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

368841

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

368850

SYH
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

368857

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

368873

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

368887

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

Small-scale

0.458

High

368896

ATU2
Copper-transporting ATPase

1

0

High-throughput

0.458

High

368922

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

368923

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

368926

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

368918

UBC7
Ubiquitin-conjugating enzyme E2 7

1

3

High-throughput

0.457

High

368849

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

368855

HSP77
Import motor subunit, mitochondrial

1

3

High-throughput

0.445

High

368861

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.445

High

368866

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

368871

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

368881

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

368882

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

368897

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.445

High

368905

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.445

High

368916

JJJ1
J protein JJJ1

1

4

High-throughput

0.445

High

368876

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

368891

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

368901

SIT1
Siderophore iron transporter 1

1

1

High-throughput

0.437

High

368904

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

368910

HOSC
Homocitrate synthase, cytosolic isozyme

1

1

High-throughput

0.437

High

368925

ENB1
Siderophore iron transporter ENB1

1

1

High-throughput

0.437

High

368853

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

368859

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.426

High

368913

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

High-throughput

0.426

High

368863

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.407

High

368909

HLJ1
Protein HLJ1

1

4

High-throughput

0.407

High

368924

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.279

Low

368929

HIF1
HAT1-interacting factor 1

1

0

High-throughput

0.269

Low

368885

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.261

Low

368867

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.249

Low

368903

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

368914

FRE4
Ferric reductase transmembrane component 4

1

0

High-throughput

0.249

Low

368928

TRMB
tRNA

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025