HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PPP5 (P53041)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	14764652
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 499
+	Hs
		369364 ESR1_HUMAN (1-595): 0: 599: 100.00		PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88
+	Hs
		369332 ESR1_HUMAN (1-595): 0: 599: 100.00		PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69
+	Hs
		369103 ESR1_HUMAN (1-595): 0: 599: 100.00		PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88
+	Hs
		369309 ESR1_HUMAN (1-595): 0: 599: 100.00		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Mm
		587097 ESR1_MOUSE (1-595): 0: 570: 88.98		PP1G_MOUSE (196-488): 1.32e-154: 444: 36.88
+	Hs
		858657 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PPP5_HUMAN (1-499): 0: 575: 100.00
+	Hs
		377203 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		PPP5_HUMAN (1-499): 0: 575: 100.00
+	Hs
		437629 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		PPP5_HUMAN (1-499): 0: 575: 100.00
+	Hs
		915249 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69
+	Hs
		737951 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88
+	Hs
		906550 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PP1B_HUMAN (203-490): 1.32e-154: 444: 36.09
+	Hs
		906054 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Hs
		320201 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88
+	Hs
		320195 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69
+	Hs
		437630 MCR_HUMAN (21-554): 3.98e-103: 335: 22.01		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Hs
		414470 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		PPP5_HUMAN (1-499): 0: 575: 100.00
+	Hs
		487258 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PPP5_HUMAN (1-499): 0: 575: 100.00
+	Hs
		487319 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88
+	Hs
		487291 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PP1B_HUMAN (203-490): 1.32e-154: 444: 36.09
+	Hs
		487290 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79