HitPredict

Interactor 1: A2MG (P01023)
Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)
Gene: A2M

Interactor 2: KLK3 (P07288)
Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase)
Gene: KLK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	1702714
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	A2M_recep~Trypsin, MG2~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1474 Hs			1 261
+	Hs
		369584 A2MG_HUMAN (1-1474): 0: 1949: 100.00		KLK1_HUMAN (1-260): 9.13e-116: 334: 60.54
+	Hs
		369776 A2MG_HUMAN (1-1474): 0: 1949: 100.00		KLK13_HUMAN (1-259): 3.82e-105: 307: 42.80
+	Hs
		210639 A2MG_HUMAN (1-1474): 0: 1949: 100.00		KLK10_HUMAN (3-260): 3.47e-89: 267: 34.10
+	Mm
		704320 MUG1_MOUSE (1-1473): 0: 1794: 58.33		KLK8_MOUSE (5-259): 4.66e-102: 299: 43.14
+	Hs
		369607 A2MG_HUMAN (1-1474): 0: 1949: 100.00		GRAA_HUMAN (21-257): 2.1e-40: 142: 35.77
+	Hs
		210640 CO3_HUMAN (27-1473): 0: 1264: 22.29		KLK10_HUMAN (3-260): 3.47e-89: 267: 34.10
+	Hs
		210693 CO4B_HUMAN (23-1471): 0: 1209: 22.97		KLK10_HUMAN (3-260): 3.47e-89: 267: 34.10
+	Hs
		210641 CO5_HUMAN (12-1464): 0: 1156: 21.41		KLK10_HUMAN (3-260): 3.47e-89: 267: 34.10
+	Hs
		663556 CD109_HUMAN (15-1468): 0: 1276: 26.78		CMA1_HUMAN (25-260): 9.94e-40: 139: 38.12
+	Mm
		398780 CD109_MOUSE (15-1464): 0: 1258: 25.69		CFAD_MOUSE (24-260): 3.07e-37: 133: 35.37