Protein: KLK1
Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein)

Gene: KLK1
Organism: Homo sapiens
Interactions: 56
UniProt ID: P06870

Gene Ontology (top 5):
GO:0003073 - regulation of systemic arterial blood pressure
GO:0004252 - serine-type endopeptidase activity
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0030141 - secretory granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366460

UROK
Urokinase-type plasminogen activator

1

16

High-throughput

0.691

High

449592

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.656

High

369234

ANT3
Antithrombin-III

1

20

Small-scale

0.647

High

369296

A1AT
Alpha-1-antitrypsin

1

20

Small-scale

0.647

High

369584

A2MG
Alpha-2-macroglobulin

1

10

Small-scale

0.647

High

402467

PROC
Vitamin K-dependent protein C

1

17

Small-scale

0.647

High

449594

KAIN
Kallistatin

1

20

Small-scale

0.647

High

449604

ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

1

5

Small-scale

0.647

High

449588

CFAH
Complement factor H

1

15

Small-scale

0.575

High

449618

RUSF1
RUS family member 1

2

1

High-throughput

0.549

High

449620

S2533
Solute carrier family 25 member 33

2

20

High-throughput

0.549

High

449632

ORNT1
Mitochondrial ornithine transporter 1

2

20

High-throughput

0.549

High

282813

CRLF1
Cytokine receptor-like factor 1

1

4

High-throughput

0.536

High

302235

STC2
Stanniocalcin-2

1

3

High-throughput

0.536

High

336180

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

3

High-throughput

0.536

High

350673

NOE2
Noelin-2

1

3

High-throughput

0.536

High

449589

BIP
Endoplasmic reticulum chaperone BiP

1

12

High-throughput

0.536

High

449593

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

18

High-throughput

0.536

High

449600

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

3

High-throughput

0.536

High

449607

TBB8
Tubulin beta-8 chain

1

20

High-throughput

0.536

High

449616

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

1

High-throughput

0.536

High

449623

CHRD
Chordin

1

17

High-throughput

0.536

High

449630

DD19B
ATP-dependent RNA helicase DDX19B

1

7

High-throughput

0.536

High

449631

TTF2
Transcription termination factor 2

1

9

High-throughput

0.536

High

449595

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.513

High

449606

PWP3A
PWWP domain-containing DNA repair factor 3A

1

0

High-throughput

0.513

High

370394

KNG1
Kininogen-1

1

6

Small-scale

0.501

High

227014

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

1

20

High-throughput

0.489

High

449590

ADT1
ADP/ATP translocase 1

1

15

High-throughput

0.489

High

449591

FGFR3
Fibroblast growth factor receptor 3

1

12

High-throughput

0.489

High

449597

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.489

High

449601

SEM3B
Semaphorin-3B

1

10

High-throughput

0.489

High

449609

MTX3
Metaxin-3

1

1

High-throughput

0.489

High

449612

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

1

High-throughput

0.489

High

449614

SUMF1
Formylglycine-generating enzyme

1

4

High-throughput

0.489

High

449615

MOT10
Monocarboxylate transporter 10

1

2

High-throughput

0.489

High

449617

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

1

High-throughput

0.489

High

449627

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

8

High-throughput

0.489

High

449603

LAMC2
Laminin subunit gamma-2

1

13

High-throughput

0.445

High

449605

MA2A1
Alpha-mannosidase 2

1

10

High-throughput

0.445

High

449621

RSRP1
Arginine/serine-rich protein 1

1

1

High-throughput

0.445

High

449629

PLXA1
Plexin-A1

1

16

High-throughput

0.445

High

449596

PPOX
Protoporphyrinogen oxidase

1

2

High-throughput

0.407

High

449598

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

18

High-throughput

0.407

High

449599

AP1S1
AP-1 complex subunit sigma-1A

1

4

High-throughput

0.407

High

449602

LAMB3
Laminin subunit beta-3

1

10

High-throughput

0.407

High

449611

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

12

High-throughput

0.407

High

449625

S38AA
Solute carrier family 38 member 10

1

2

High-throughput

0.407

High

449628

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

8

High-throughput

0.407

High

449613

TRM2A
tRNA

1

0

High-throughput

0.279

Low

449619

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.279

Low

449622

HIG2A
HIG1 domain family member 2A, mitochondrial

1

0

High-throughput

0.279

Low

449624

NSUN3
tRNA

1

0

High-throughput

0.279

Low

449626

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.279

Low

449608

TM177
Transmembrane protein 177

1

0

High-throughput

0.232

Low

449610

LYPL1
Lysophospholipase-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025