HitPredict

Interactor 1: CO3 (P01026)
Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc) (Neutrophil chemotactic factor-2) (ENCF-2); Complement C3 alpha chain; C3a anaphylatoxin (Neutrophil chemotactic factor-1) (ENCF-1); Acylation stimulating protein (ASP) (C3adesArg); Complement C3b (Complement C3b-alpha' chain); Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: Q6MG73 (Q6MG73)
Complement C2 (EC 3.4.21.43) (C3/C5 convertase)
Gene: C2

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 9688553
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains A2M~Sushi, A2M_BRD~Sushi, A2M_BRD~VWA, A2M_recep~Trypsin, C3_CUB1~Trypsin, C3_CUB1~VWA, C3_CUB2~Sushi, C3_CUB2~Trypsin, C3_CUB2~VWA, MG1~Sushi, MG1~Trypsin, MG1~VWA, MG2~Sushi, MG2~Trypsin, MG2~VWA, MG4~Sushi, NTR~Sushi, NTR~VWA, Sushi~TED_complement, TED_complement~VWA
Common GO terms GO:0005576 - extracellular region
GO:0006956 - complement activation
GO:0006958 - complement activation, classical pathway
GO:0045087 - innate immune response
GO:2000427 - positive regulation of apoptotic cell clearance
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 1663
Rn

1 758
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Last updated: 11Aug2025