Protein: CFAB
Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Glycine-rich beta glycoprotein) (GBG) (PBF2) (Properdin factor B) [Cleaved into: Complement factor B Ba (Ba); Complement factor B Bb (Bb)]

Gene: CFAB, CFB
Organism: Homo sapiens
Interactions: 42
UniProt ID: P00751

Gene Ontology (top 5):
GO:0001848 - complement binding
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366559

CO3
Complement C3

3

12

Small-scale

0.834

High

132958

MATN2
Matrilin-2

1

16

High-throughput

0.691

High

210636

KLK10
Kallikrein-10

1

19

High-throughput

0.691

High

366576

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.691

High

366571

PROP
Properdin

1

7

Small-scale

0.647

High

366575

NPC2
NPC intracellular cholesterol transporter 2

2

1

High-throughput

0.628

High

366587

RSPRY
RING finger and SPRY domain-containing protein 1

2

4

High-throughput

0.628

High

366592

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

366560

CYTS
Cystatin-S

1

3

High-throughput

0.536

High

366562

ALBU
Albumin

1

2

High-throughput

0.536

High

366566

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.536

High

366570

CALR
Calreticulin

1

8

High-throughput

0.536

High

366572

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

366574

EPHA4
Ephrin type-A receptor 4

1

19

High-throughput

0.536

High

366579

TBB3
Tubulin beta-3 chain

1

20

High-throughput

0.536

High

366580

GRB14
Growth factor receptor-bound protein 14

1

9

High-throughput

0.536

High

366581

TBB8
Tubulin beta-8 chain

1

20

High-throughput

0.536

High

366591

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

366586

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

366563

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.501

High

366582

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

1

High-throughput

0.489

High

366583

OAF
Out at first protein homolog

1

2

High-throughput

0.489

High

366588

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

5

High-throughput

0.489

High

366590

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

366593

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

366594

LAMC3
Laminin subunit gamma-3

1

5

High-throughput

0.481

High

366561

FINC
Fibronectin

1

7

Small-scale

0.479

High

366567

DESP
Desmoplakin

1

5

High-throughput

0.479

High

366569

NDKB
Nucleoside diphosphate kinase B

1

4

High-throughput

0.479

High

366577

H11
Histone H1.1

1

1

High-throughput

0.470

High

366564

AMY1B
Alpha-amylase 1B

1

1

High-throughput

0.445

High

366568

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.439

High

277219

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.437

High

366565

H14
Histone H1.4

1

1

High-throughput

0.437

High

366578

FOXO1
Forkhead box protein O1

1

3

High-throughput

0.437

High

366589

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

104713

F6XY72
nucleoside-diphosphate kinase

1

4

High-throughput

0.407

High

366584

GDPD1
Lysophospholipase D GDPD1

3

0

High-throughput

0.347

High

366585

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

219105

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.251

Low

360692

COX3
Cytochrome c oxidase subunit 3

1

0

Small-scale

0.249

Low

366573

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025