HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	29467282, 35013218, 36424410, 17314511, 21150319
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010628 - positive regulation of gene expression GO:0032204 - regulation of telomere maintenance GO:0048471 - perinuclear region of cytoplasm and 1 others more... GO:0071456 - cellular response to hypoxia
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 664
+	Hs
		371052 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		K2C5_HUMAN (24-390): 2e-117: 365: 25.95
+	Hs
		370873 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		K2C6A_HUMAN (23-407): 4.96e-116: 360: 23.71
+	Hs
		370896 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		K2C6B_HUMAN (24-407): 4.84e-115: 357: 23.51
+	Hs
		405744 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		K2C5_HUMAN (24-390): 2e-117: 365: 25.95
+	Hs
		385213 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		K2C6A_HUMAN (23-407): 4.96e-116: 360: 23.71
+	Hs
		371819 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		LMNB2_HUMAN (21-581): 2.95e-51: 189: 52.59
+	Hs
		371149 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45
+	Hs
		370975 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		VIME_HUMAN (27-389): 3.96e-31: 129: 28.93
+	Hs
		385350 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00
+	Hs
		372479 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		K2C73_HUMAN (226-558): 7.25e-09: 60.6: 11.63
+	Hs
		385512 SRBP1_HUMAN (95-453): 7.2e-33: 134: 16.19		LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00
+	Hs
		405784 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45
+	Hs
		405701 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		VIME_HUMAN (27-389): 3.96e-31: 129: 28.93
+	Hs
		405746 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		GFAP_HUMAN (27-427): 1.13e-28: 121: 27.43
+	Hs
		634331 SRBP1_HUMAN (95-453): 7.2e-33: 134: 16.19		LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45