HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: THIO (P10599)
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Gene: TXN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37045861
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0033138 - positive regulation of peptidyl-serine phosphorylation
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 105
+	Hs
		374547 RAF1_HUMAN (1-648): 0: 652: 100.00		TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00
+	Hs
		373617 RAF1_HUMAN (1-648): 0: 652: 100.00		PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85
+	Hs
		373533 RAF1_HUMAN (1-648): 0: 652: 100.00		PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22
+	At
		1114780 Y5188_ARATH (10-643): 3.28e-164: 494: 16.40		TRXH3_ARATH (2-104): 7.63e-34: 114: 39.05
+	At
		83488 Y1756_ARATH (2-631): 5.57e-161: 486: 15.78		TRXH3_ARATH (2-104): 7.63e-34: 114: 39.05
+	Hs
		423128 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22
+	At
		84146 Y2289_ARATH (12-644): 3.44e-159: 481: 16.54		TRXH5_ARATH (2-104): 1.46e-34: 116: 35.24
+	Hs
		423113 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22
+	At
		84822 Y5129_ARATH (76-608): 5.03e-155: 462: 17.38		TRXH5_ARATH (2-104): 1.46e-34: 116: 35.24