HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	16322212, 16093354, 28146421
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 840
+	Hs
		374620 RAF1_HUMAN (1-648): 0: 652: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		542830 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		320806 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Gg
		982831 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		Q5F3J8_CHICK (1-840): 0: 947: 64.32
+	Hs
		522818 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		412053 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		523090 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		412286 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		373593 RAF1_HUMAN (1-648): 0: 652: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		373642 RAF1_HUMAN (1-648): 0: 652: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		374331 RAF1_HUMAN (1-648): 0: 652: 100.00		Q53FC7_HUMAN (587-690): 3.01e-16: 85.1: 22.86
+	Hs
		503368 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Mm
		655941 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		HSP7C_MOUSE (564-692): 1.76e-19: 95.5: 16.15
+	Hs
		488545 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		542812 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		488563 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		503340 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		433227 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		411965 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92