HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: TCPQ (P50990)
T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)
Gene: CCT8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	25852190, 31980649, 36244648, unassigned2173, 37045861
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 548
+	Hs
		374759 RAF1_HUMAN (1-648): 0: 652: 100.00		TCPH_HUMAN (9-538): 0: 564: 26.39
+	Hs
		373876 RAF1_HUMAN (1-648): 0: 652: 100.00		TCPG_HUMAN (10-547): 0: 558: 28.21
+	Hs
		373868 RAF1_HUMAN (1-648): 0: 652: 100.00		TCPE_HUMAN (2-524): 0: 535: 29.62
+	Hs
		373897 RAF1_HUMAN (1-648): 0: 652: 100.00		TCPD_HUMAN (19-525): 0: 530: 28.24
+	Hs
		373647 RAF1_HUMAN (1-648): 0: 652: 100.00		TCPA_HUMAN (21-541): 0: 528: 29.89
+	Hs
		488623 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TCPQ_HUMAN (1-548): 0: 616: 100.00
+	Zm
		26117 A0A1D6IZ90_MAIZE (77-608): 8.26e-158: 470: 17.76		K7UCH1_MAIZE (10-543): 0: 612: 52.22
+	Hs
		542913 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		TCPH_HUMAN (9-538): 0: 564: 26.39
+	Hs
		488790 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TCPH_HUMAN (9-538): 0: 564: 26.39
+	Hs
		488618 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TCPG_HUMAN (10-547): 0: 558: 28.21
+	Hs
		488624 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TCPD_HUMAN (19-525): 0: 530: 28.24
+	Hs
		488566 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		TCPA_HUMAN (21-541): 0: 528: 29.89
+	Hs
		412092 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPQ_HUMAN (1-548): 0: 616: 100.00
+	Hs
		433290 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		TCPG_HUMAN (10-547): 0: 558: 28.21
+	Hs
		412086 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPG_HUMAN (10-547): 0: 558: 28.21
+	Hs
		412084 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPE_HUMAN (2-524): 0: 535: 29.62
+	Hs
		433248 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		TCPA_HUMAN (21-541): 0: 528: 29.89
+	Hs
		412093 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPD_HUMAN (19-525): 0: 530: 28.24
+	Hs
		411996 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		TCPA_HUMAN (21-541): 0: 528: 29.89
+	Hs
		1217976 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		TCPQM_HUMAN (32-545): 7.5e-75: 249: 32.17