HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	36244648, 37045861
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 1647
+	Hs
		229274 RAF1_HUMAN (1-648): 0: 652: 100.00		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Hs
		373731 RAF1_HUMAN (1-648): 0: 652: 100.00		SMCA1_HUMAN (639-1619): 0: 832: 28.82
+	Hs
		374244 RAF1_HUMAN (1-648): 0: 652: 100.00		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		374134 RAF1_HUMAN (1-648): 0: 652: 100.00		CHD3_HUMAN (300-1646): 0: 711: 20.80
+	Hs
		151471 RAF1_HUMAN (1-648): 0: 652: 100.00		CHD2_HUMAN (343-1449): 0: 682: 26.93
+	Hs
		488761 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		CHD6_HUMAN (393-1488): 0: 695: 24.31
+	Hs
		229292 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Hs
		522800 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		SMCA1_HUMAN (639-1619): 0: 832: 28.82
+	Hs
		522990 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		375013 RAF1_HUMAN (1-648): 0: 652: 100.00		CHD7_HUMAN (104-638): 1.93e-11: 71.7: 8.99