HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras, PH~Ras, PH_Tiam1~Ras, RBD~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1591
+	Hs
		375469 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		TIAM1_HUMAN (1-1591): 0: 1890: 100.00
+	Hs
		1092434 RAB35_HUMAN (4-171): 6.54e-84: 247: 34.71		TIAM1_HUMAN (1-1591): 0: 1890: 100.00
+	Hs
		374561 RASH_HUMAN (16-188): 6.69e-79: 234: 84.39		TIAM1_HUMAN (1-1591): 0: 1890: 100.00
+	Hs
		956271 RAB2A_HUMAN (4-185): 5.47e-74: 223: 31.52		TIAM1_HUMAN (1-1591): 0: 1890: 100.00
+	Hs
		374381 RASH_HUMAN (16-188): 6.69e-79: 234: 84.39		VAV_HUMAN (954-1591): 8.61e-89: 311: 15.22
+	Hs
		375645 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		FGD6_HUMAN (764-1457): 1.94e-80: 295: 15.84
+	Hs
		375552 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		ITSN1_HUMAN (990-1425): 4.7e-76: 282: 18.04
+	Hs
		1144919 RAB35_HUMAN (4-171): 6.54e-84: 247: 34.71		ITSN1_HUMAN (990-1425): 4.7e-76: 282: 18.04
+	Hs
		374703 RASH_HUMAN (16-188): 6.69e-79: 234: 84.39		FGD6_HUMAN (764-1457): 1.94e-80: 295: 15.84
+	Hs
		374620 RASH_HUMAN (16-188): 6.69e-79: 234: 84.39		ITSN1_HUMAN (990-1425): 4.7e-76: 282: 18.04
+	Hs
		976290 RB11A_HUMAN (4-184): 8.81e-75: 225: 33.88		ITSN1_HUMAN (990-1425): 4.7e-76: 282: 18.04
+	Hs
		299501 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		TRIO_HUMAN (1029-1589): 3.2e-60: 231: 16.29
+	Hs
		299547 RAB35_HUMAN (4-171): 6.54e-84: 247: 34.71		TRIO_HUMAN (1029-1589): 3.2e-60: 231: 16.29
+	Hs
		299531 RB11A_HUMAN (4-184): 8.81e-75: 225: 33.88		TRIO_HUMAN (1029-1589): 3.2e-60: 231: 16.29
+	Dm
		1321337 Q962I2_DROME (4-170): 1.84e-59: 186: 51.79		Q8MSP7_DROME (1041-1240): 5.85e-14: 79.7: 29.50
+	Dm
		74961 RALA_DROME (4-169): 1.5e-59: 186: 52.70		B3DN64_DROME (1041-1240): 5.8e-14: 79.7: 29.50
+	Sc
		376206 RAS2_YEAST (3-179): 5.78e-58: 186: 61.54		CDC24_YEAST (1043-1244): 6.38e-14: 79.3: 29.56
+	Sc
		376175 RAS1_YEAST (3-164): 2.31e-57: 184: 64.42		CDC24_YEAST (1043-1244): 6.38e-14: 79.3: 29.56