Protein: TIAM1
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)

Gene: TIAM1
Organism: Homo sapiens
Interactions: 207
UniProt ID: Q13009

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
GO:0007160 - cell-matrix adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

966256

1433G
14-3-3 protein gamma

6

20

High-throughput

0.943

High

729790

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.916

High

1049244

1433F
14-3-3 protein eta

5

20

High-throughput

0.916

High

690959

1433T
14-3-3 protein theta

4

20

High-throughput

0.892

High

990164

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.892

High

988327

RAC1
Ras-related C3 botulinum toxin substrate 1

4

20

Small-scale

0.878

High

168681

CSKP
Peripheral plasma membrane protein CASK

3

18

Small-scale

0.864

High

971463

1433E
14-3-3 protein epsilon

3

9

High-throughput

0.847

High

955110

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.768

High

962003

RHOA
Transforming protein RhoA

2

20

High-throughput

0.768

High

375469

RASK
GTPase KRas

2

18

High-throughput

0.754

High

977971

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1092467

PARD3
Partitioning defective 3 homolog

2

10

Small-scale

0.754

High

1092519

FBW1A
F-box/WD repeat-containing protein 1A

1

8

Small-scale

0.747

High

1092429

SNTB2
Beta-2-syntrophin

2

10

High-throughput

0.737

High

876840

KC1A
Casein kinase I isoform alpha

1

2

Small-scale

0.724

High

1092481

NEB2
Neurabin-2

1

20

Small-scale

0.713

High

174238

ARHGA
Rho guanine nucleotide exchange factor 10

1

17

High-throughput

0.698

High

631643

RAB6A
Ras-related protein Rab-6A

1

3

High-throughput

0.698

High

1006058

DLG4
Disks large homolog 4

1

10

High-throughput

0.698

High

1091486

DLG1
Disks large homolog 1

1

8

High-throughput

0.698

High

1092428

SNTA1
Alpha-1-syntrophin

1

11

High-throughput

0.698

High

1092520

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

20

High-throughput

0.698

High

585784

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

10

High-throughput

0.691

High

1092494

WNK1
Serine/threonine-protein kinase WNK1

1

16

High-throughput

0.691

High

374561

RASH
GTPase HRas

1

14

Small-scale

0.665

High

424656

KPCG
Protein kinase C gamma type

1

20

Small-scale

0.647

High

436666

KPCB
Protein kinase C beta type

1

19

Small-scale

0.647

High

603257

KPCA
Protein kinase C alpha type

1

19

Small-scale

0.647

High

994195

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

7

Small-scale

0.647

High

1034987

KPCE
Protein kinase C epsilon type

1

17

Small-scale

0.647

High

1051214

KPCZ
Protein kinase C zeta type

1

19

Small-scale

0.647

High

1051916

KPCD
Protein kinase C delta type

1

19

Small-scale

0.647

High

1092507

NRBP
Nuclear receptor-binding protein

1

1

High-throughput

0.625

High

176822

DCLK1
Serine/threonine-protein kinase DCLK1

1

13

High-throughput

0.618

High

208662

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.618

High

269547

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

7

High-throughput

0.618

High

341042

DIRA3
GTP-binding protein Di-Ras3

1

7

High-throughput

0.618

High

373905

RASN
GTPase NRas

1

18

High-throughput

0.618

High

463491

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.618

High

601262

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

730553

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

885756

KC1E
Casein kinase I isoform epsilon

1

10

Small-scale

0.618

High

956271

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.618

High

975010

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.618

High

1015399

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1025539

CDK16
Cyclin-dependent kinase 16

1

2

High-throughput

0.618

High

1065689

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

14

High-throughput

0.618

High

1092430

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

10

High-throughput

0.618

High

1092434

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.618

High

1092442

SPD2A
SH3 and PX domain-containing protein 2A

1

19

High-throughput

0.618

High

1092446

PKHA7
Pleckstrin homology domain-containing family A member 7

1

16

High-throughput

0.618

High

1092453

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1092456

PHLB2
Pleckstrin homology-like domain family B member 2

1

15

High-throughput

0.618

High

1092461

KSR1
Kinase suppressor of Ras 1

1

17

High-throughput

0.618

High

1092479

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

10

High-throughput

0.618

High

1092484

RTKN
Rhotekin

1

2

High-throughput

0.618

High

1092495

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1092496

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1092500

LIN7C
Protein lin-7 homolog C

1

16

High-throughput

0.618

High

1092503

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.618

High

1092513

FBW1B
F-box/WD repeat-containing protein 11

1

8

High-throughput

0.618

High

1092516

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

1092518

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

8

Small-scale

0.618

High

1092433

SETB1
Histone-lysine N-methyltransferase SETDB1

2

4

Small-scale

0.576

High

547437

DMD
Dystrophin

2

19

High-throughput

0.571

High

940386

MAZ
Myc-associated zinc finger protein

2

2

High-throughput

0.571

High

1092447

FIP1
Pre-mRNA 3'-end-processing factor FIP1

2

1

High-throughput

0.571

High

1092522

DTNA
Dystrobrevin alpha

2

2

High-throughput

0.571

High

616750

SDC1
Syndecan-1

1

4

Small-scale

0.566

High

165318

PSA7
Proteasome subunit alpha type-7

1

1

High-throughput

0.561

High

371902

MYC
Myc proto-oncogene protein

1

9

Small-scale

0.561

High

592932

ANK1
Ankyrin-1

1

9

Small-scale

0.561

High

1092440

FND3B
Fibronectin type III domain-containing protein 3B

1

7

Small-scale

0.555

High

230527

KIF1C
Kinesin-like protein KIF1C

1

10

High-throughput

0.553

High

245225

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

14

High-throughput

0.553

High

1092427

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

8

Small-scale

0.553

High

1092441

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

6

High-throughput

0.553

High

1092480

TESK2
Dual specificity testis-specific protein kinase 2

1

5

High-throughput

0.553

High

1092488

WDR33
pre-mRNA 3' end processing protein WDR33

1

9

High-throughput

0.553

High

1092497

KI13B
Kinesin-like protein KIF13B

1

10

High-throughput

0.553

High

1092517

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

17

High-throughput

0.553

High

139129

KRIT1
Krev interaction trapped protein 1

1

7

High-throughput

0.541

High

226763

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

2

High-throughput

0.541

High

384662

CRYAB
Alpha-crystallin B chain

1

2

High-throughput

0.541

High

882469

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.541

High

899655

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

1

High-throughput

0.541

High

906398

DHB4
Peroxisomal multifunctional enzyme type 2

1

1

High-throughput

0.541

High

1092457

DAAM2
Disheveled-associated activator of morphogenesis 2

1

2

High-throughput

0.541

High

1092460

DZIP1
Cilium assembly protein DZIP1

1

12

High-throughput

0.541

High

1092471

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.541

High

1092475

AP2M1
AP-2 complex subunit mu

1

3

High-throughput

0.541

High

1092492

ATG5
Autophagy protein 5

1

1

High-throughput

0.541

High

1092501

TBC23
TBC1 domain family member 23

1

1

High-throughput

0.541

High

563701

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.536

High

1089625

ILF3
Interleukin enhancer-binding factor 3

1

1

High-throughput

0.536

High

1092468

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

6

Small-scale

0.536

High

1092478

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

2

2

High-throughput

0.521

High

180279

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.518

High

190674

MRP5
ATP-binding cassette sub-family C member 5

1

0

High-throughput

0.518

High

858906

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.518

High

1092439

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

0

High-throughput

0.518

High

1092462

ZNF34
Zinc finger protein 34

1

0

High-throughput

0.518

High

1092489

SENP6
Sentrin-specific protease 6

1

0

High-throughput

0.518

High

1092491

SHRPN
Sharpin

1

0

High-throughput

0.518

High

1092510

ENPP5
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5

1

0

High-throughput

0.518

High

1092458

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

7

Small-scale

0.515

High

269918

SDC3
Syndecan-3

1

6

Small-scale

0.501

High

507899

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.501

High

591288

CD44
CD44 antigen

1

3

Small-scale

0.501

High

726657

SDC4
Syndecan-4

1

2

Small-scale

0.501

High

760434

SDC2
Syndecan-2

1

3

Small-scale

0.501

High

67215

ABTB3
Ankyrin repeat- and BTB/POZ domain-containing protein 3

1

8

High-throughput

0.494

High

244085

ZN292
Zinc finger protein 292

1

1

High-throughput

0.494

High

472695

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.494

High

541985

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.494

High

881044

NASP
Nuclear autoantigenic sperm protein

1

3

High-throughput

0.494

High

939780

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

1

High-throughput

0.494

High

942095

SOX10
Transcription factor SOX-10

1

2

High-throughput

0.494

High

1092435

RYR3
Ryanodine receptor 3

1

3

High-throughput

0.494

High

1092437

NDF2
Neurogenic differentiation factor 2

1

1

High-throughput

0.494

High

1092450

ZN793
Zinc finger protein 793

1

2

High-throughput

0.494

High

1092464

ZBT44
Zinc finger and BTB domain-containing protein 44

1

3

High-throughput

0.494

High

1092472

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

4

High-throughput

0.494

High

1092477

ZN558
Zinc finger protein 558

1

2

High-throughput

0.494

High

1092490

ZN350
Zinc finger protein 350

1

2

High-throughput

0.494

High

1092509

MBD1
Methyl-CpG-binding domain protein 1

1

1

High-throughput

0.494

High

1092463

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

9

High-throughput

0.489

High

1092424

SRSF5
Serine/arginine-rich splicing factor 5

1

2

Small-scale

0.481

High

1092470

CBP
CREB-binding protein

1

3

Small-scale

0.481

High

1092486

OSBL1
Oxysterol-binding protein-related protein 1

1

1

Small-scale

0.481

High

189544

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

251577

CCNT1
Cyclin-T1

1

5

High-throughput

0.479

High

281315

GGYF1
GRB10-interacting GYF protein 1

1

9

High-throughput

0.479

High

299174

FLOT1
Flotillin-1

1

9

High-throughput

0.479

High

339076

NADK
NAD kinase

1

1

High-throughput

0.479

High

540430

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

584751

NDKA
Nucleoside diphosphate kinase A

1

3

Small-scale

0.479

High

603958

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

637891

NF1
Neurofibromin

1

8

High-throughput

0.479

High

719217

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

719320

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

845622

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.479

High

940940

HDAC4
Histone deacetylase 4

1

14

High-throughput

0.479

High

1041034

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1045234

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1091388

ANK3
Ankyrin-3

1

9

Small-scale

0.479

High

1092426

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

1092431

CUL4B
Cullin-4B

1

9

High-throughput

0.479

High

1092438

OCLN
Occludin

1

2

High-throughput

0.479

High

1092444

DEN4C
DENN domain-containing protein 4C

1

2

High-throughput

0.479

High

1092449

GGYF2
GRB10-interacting GYF protein 2

1

20

High-throughput

0.479

High

1092451

SYDE1
Rho GTPase-activating protein SYDE1

1

7

High-throughput

0.479

High

1092459

DDX42
ATP-dependent RNA helicase DDX42

1

2

High-throughput

0.479

High

1092465

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1092466

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

1092483

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1092493

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

1092498

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

6

High-throughput

0.479

High

1092504

CING
Cingulin

1

5

High-throughput

0.479

High

1092506

LIMA1
LIM domain and actin-binding protein 1

1

9

High-throughput

0.479

High

1092511

NGAP
Ras GTPase-activating protein nGAP

1

7

High-throughput

0.479

High

1092512

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.479

High

1092514

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

1092521

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1092523

KCTD3
BTB/POZ domain-containing protein KCTD3

1

12

High-throughput

0.479

High

1092425

TIF1B
Transcription intermediary factor 1-beta

1

5

Small-scale

0.470

High

252055

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

417404

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

840692

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.458

High

1092455

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1092482

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1092476

SPTCS
Spatacsin

1

2

Small-scale

0.457

High

172757

XPO1
Exportin-1

1

7

High-throughput

0.445

High

379509

IGHM
Immunoglobulin heavy constant mu

1

4

High-throughput

0.445

High

379638

IGHA1
Immunoglobulin heavy constant alpha 1

1

4

High-throughput

0.445

High

1092505

SL9A2
Sodium/hydrogen exchanger 2

1

1

High-throughput

0.445

High

1092436

SYCP1
Synaptonemal complex protein 1

1

6

Small-scale

0.439

High

1092473

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

3

Small-scale

0.439

High

181702

CTDSL
CTD small phosphatase-like protein

1

3

High-throughput

0.437

High

327245

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

355510

NSD2
Histone-lysine N-methyltransferase NSD2

1

4

Small-scale

0.437

High

895545

SERPH
Serpin H1

1

7

High-throughput

0.437

High

932858

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

4

High-throughput

0.437

High

1053361

CTSL2
CTD small phosphatase-like protein 2

1

3

High-throughput

0.437

High

1092432

ZN638
Zinc finger protein 638

1

2

High-throughput

0.437

High

1092445

AN34A
Ankyrin repeat domain-containing protein 34A

1

18

High-throughput

0.437

High

1092448

LRC31
Leucine-rich repeat-containing protein 31

1

3

High-throughput

0.437

High

1092469

SRS12
Serine/arginine-rich splicing factor 12

1

4

High-throughput

0.437

High

1092474

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1092508

ATIF1
ATPase inhibitor, mitochondrial

1

1

High-throughput

0.437

High

1092515

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.437

High

1092524

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

1

High-throughput

0.437

High

1092452

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.407

High

552953

PIP
Prolactin-inducible protein

2

0

High-throughput

0.313

High

255619

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.282

High

359645

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.282

High

913694

ZN133
Zinc finger protein 133

1

0

High-throughput

0.282

High

1016815

H33
Histone H3.3

1

0

High-throughput

0.282

High

1071237

CCD15
Coiled-coil domain-containing protein 15

1

0

High-throughput

0.282

High

1092443

DAAF9
Dynein axonemal assembly factor 9

1

0

High-throughput

0.282

High

1092454

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.282

High

1092499

ZHANG
CREB/ATF bZIP transcription factor

1

0

High-throughput

0.282

High

1092487

CNTP4
Contactin-associated protein-like 4

1

0

Small-scale

0.279

Low

390031

ALBU
Albumin

1

0

High-throughput

0.279

Low

1092485

NUSAP
Nucleolar and spindle-associated protein 1

1

0

High-throughput

0.249

Low

1092502

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025