HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36244648, 38496616
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007190 - activation of adenylate cyclase activity GO:0046872 - metal ion binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 394
+	Hs
		373499 RAF1_HUMAN (1-648): 0: 652: 100.00		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		374020 RAF1_HUMAN (1-648): 0: 652: 100.00		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		542856 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		488664 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00
+	Hs
		391319 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Gg
		837589 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		GNAI2_CHICK (1-394): 6.21e-158: 450: 37.56
+	Mm
		444633 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		GNAI2_MOUSE (1-394): 7.23e-158: 449: 38.83
+	Mm
		655984 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		GNAI3_MOUSE (1-394): 1.35e-153: 439: 38.07