HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35271311, 38496616
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 457
+	Hs
		374083 RAF1_HUMAN (1-648): 0: 652: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		542876 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		488708 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Gg
		982843 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		Q646T7_CHICK (1-446): 2e-137: 404: 83.86
+	Hs
		488688 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		374114 RAF1_HUMAN (1-648): 0: 652: 100.00		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		375059 RAF1_HUMAN (1-648): 0: 652: 100.00		FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70
+	Hs
		118664 RAF1_HUMAN (1-648): 0: 652: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		373773 RAF1_HUMAN (1-648): 0: 652: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		542932 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		FKBPL_HUMAN (133-414): 4.04e-51: 178: 25.70
+	Hs
		118681 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		488716 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		1034905 KSR2_HUMAN (332-623): 6.72e-43: 168: 34.43		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		118683 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118675 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118671 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		259949 KSR2_HUMAN (332-623): 6.72e-43: 168: 34.43		FKBP6_HUMAN (2-137): 2.27e-35: 135: 35.97