HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: RHES (Q96D21)
GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2)
Gene: RASD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	14724584, 16757351
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras, RBD~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 266
+	Hs
		373973 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB8A_HUMAN (12-197): 1.68e-80: 242: 26.20
+	Hs
		374007 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1A_HUMAN (10-219): 4.07e-79: 239: 21.86
+	Hs
		374854 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1B_HUMAN (12-219): 3.33e-77: 234: 21.23
+	Hs
		373978 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB10_HUMAN (16-218): 1.11e-76: 232: 22.33
+	Hs
		374003 RAF1_HUMAN (1-648): 0: 652: 100.00		RB11A_HUMAN (10-222): 5.16e-73: 224: 20.80
+	Hs
		374694 RAF1_HUMAN (1-648): 0: 652: 100.00		DIRA2_HUMAN (18-191): 1.41e-38: 135: 43.10
+	Hs
		373983 RAF1_HUMAN (1-648): 0: 652: 100.00		RAP1B_HUMAN (20-186): 3.33e-31: 115: 39.52
+	Hs
		374009 RAF1_HUMAN (1-648): 0: 652: 100.00		RAP1A_HUMAN (20-186): 1.5e-30: 114: 39.52
+	Hs
		373580 RAF1_HUMAN (1-648): 0: 652: 100.00		RRAS_HUMAN (32-183): 4.18e-27: 106: 42.11
+	Hs
		373598 RAF1_HUMAN (1-648): 0: 652: 100.00		RALB_HUMAN (1-186): 1.85e-25: 101: 34.41
+	Hs
		373993 RAF1_HUMAN (1-648): 0: 652: 100.00		RRAS2_HUMAN (16-203): 2.12e-24: 98.6: 38.54
+	Hs
		542851 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RAB1A_HUMAN (10-219): 4.07e-79: 239: 21.86
+	Hs
		488650 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		RB11A_HUMAN (10-222): 5.16e-73: 224: 20.80
+	Hs
		542845 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RAP1B_HUMAN (20-186): 3.33e-31: 115: 39.52
+	Hs
		542852 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RAP1A_HUMAN (20-186): 1.5e-30: 114: 39.52
+	Mm
		655977 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		RAP1B_MOUSE (20-186): 3.33e-31: 115: 39.52
+	Dm
		442951 KRAF1_DROME (45-647): 6.35e-165: 491: 44.98		RAP1_DROME (20-186): 7.64e-31: 115: 38.92
+	Hs
		488055 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		RRAS_HUMAN (32-183): 4.18e-27: 106: 42.11
+	Hs
		488640 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		RRAS2_HUMAN (16-203): 2.12e-24: 98.6: 38.54
+	Hs
		488057 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		RRAS_HUMAN (32-183): 4.18e-27: 106: 42.11