HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12808105
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DIL~Ras, PDZ~Ras, RA~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1824
+	Hs
		375325 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		AFAD_HUMAN (1-1824): 0: 1266: 100.00
+	Dm
		473610 RAS1_DROME (1-170): 2.88e-90: 263: 83.53		Q8IPP3_DROME (1-1428): 0: 881: 35.83
+	Dm
		473616 RAS1_DROME (1-170): 2.88e-90: 263: 83.53		Q95TT5_DROME (1-1633): 0: 880: 32.40
+	Dm
		473602 RAS1_DROME (1-170): 2.88e-90: 263: 83.53		Q24279_DROME (639-1633): 5.72e-107: 382: 28.87
+	Hs
		374218 RASN_HUMAN (1-189): 1.05e-80: 239: 100.00		KI13B_HUMAN (184-691): 2.15e-62: 238: 13.13
+	Hs
		1140305 RAB35_HUMAN (4-171): 6.54e-84: 247: 34.71		KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72
+	Hs
		374213 RASN_HUMAN (1-189): 1.05e-80: 239: 100.00		GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06
+	Hs
		375514 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		SCRIB_HUMAN (980-1700): 5.01e-22: 106: 16.02
+	Hs
		375800 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		DLG3_HUMAN (1009-1248): 4.09e-22: 106: 18.50
+	Hs
		1122231 RAB35_HUMAN (4-171): 6.54e-84: 247: 34.71		SCRIB_HUMAN (980-1700): 5.01e-22: 106: 16.02
+	Hs
		376088 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		NEB1_HUMAN (1002-1092): 9.77e-20: 98.7: 40.00
+	Hs
		1145167 RAB35_HUMAN (4-171): 6.54e-84: 247: 34.71		NEB1_HUMAN (1002-1092): 9.77e-20: 98.7: 40.00
+	Hs
		373928 RASN_HUMAN (1-189): 1.05e-80: 239: 100.00		SCRIB_HUMAN (980-1700): 5.01e-22: 106: 16.02
+	Hs
		375462 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83
+	Hs
		1090128 RAB35_HUMAN (4-171): 6.54e-84: 247: 34.71		PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83
+	Hs
		374277 RASN_HUMAN (1-189): 1.05e-80: 239: 100.00		NEB1_HUMAN (1002-1092): 9.77e-20: 98.7: 40.00
+	Hs
		1145193 RAB35_HUMAN (4-171): 6.54e-84: 247: 34.71		MYO5A_HUMAN (1335-1824): 1.06e-12: 76.1: 9.60
+	Hs
		375750 RASK_HUMAN (16-189): 7.11e-85: 249: 85.71		INADL_HUMAN (1003-1089): 2.14e-11: 71.8: 25.81
+	Hs
		956026 RAB8A_HUMAN (4-185): 1.75e-84: 249: 36.02		MYO5B_HUMAN (1206-1821): 2.21e-09: 64.9: 7.13
+	Hs
		956013 RAB8A_HUMAN (4-185): 1.75e-84: 249: 36.02		MYO5C_HUMAN (1238-1640): 3.78e-09: 64.2: 6.81