HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: JIP3 (Q9UPT6)
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Gene: MAPK8IP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	11044439, 10523642
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0043066 - negative regulation of apoptotic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 1336
+	Hs
		523209 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Hs
		373791 RAF1_HUMAN (1-648): 0: 652: 100.00		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		373790 RAF1_HUMAN (1-648): 0: 652: 100.00		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Mm
		936589 RAF1_MOUSE (1-648): 0: 647: 97.69		ROCK2_MOUSE (2-515): 3.04e-21: 103: 11.81
+	Hs
		374373 RAF1_HUMAN (1-648): 0: 652: 100.00		MRCKA_HUMAN (2-407): 2.77e-19: 96.9: 12.93
+	Hs
		148266 RAF1_HUMAN (1-648): 0: 652: 100.00		CTRO_HUMAN (1-425): 1.46e-17: 91.4: 9.17
+	Hs
		373636 RAF1_HUMAN (1-648): 0: 652: 100.00		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		374446 RAF1_HUMAN (1-648): 0: 652: 100.00		MYH14_HUMAN (80-569): 1.98e-11: 71.2: 13.69
+	Hs
		374766 RAF1_HUMAN (1-648): 0: 652: 100.00		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56
+	Hs
		373794 RAF1_HUMAN (1-648): 0: 652: 100.00		MYH11_HUMAN (381-691): 8.22e-09: 62.6: 11.75
+	Hs
		488765 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		MY18A_HUMAN (189-793): 1.74e-25: 117: 9.00
+	Hs
		542811 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		488559 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		412287 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		MY18A_HUMAN (189-793): 1.74e-25: 117: 9.00
+	Hs
		111443 J3QRU1_HUMAN (329-607): 1.4e-105: 332: 33.92		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		433272 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		412058 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		411983 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		412330 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56