HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	27684187, 30639242, 30194290, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 543
+	Hs
		374344 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		YES_HUMAN (1-543): 0: 618: 100.00
+	Hs
		373734 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		YES_HUMAN (1-543): 0: 618: 100.00
+	Hs
		463098 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		YES_HUMAN (1-543): 0: 618: 100.00
+	Hs
		374371 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		SRC_HUMAN (1-543): 0: 602: 74.22
+	Rn
		628681 RASH_RAT (1-188): 8.44e-87: 254: 86.77		SRC_RAT (1-543): 0: 601: 73.67
+	Hs
		373749 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		SRC_HUMAN (1-543): 0: 602: 74.22
+	Hs
		374341 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		FYN_HUMAN (1-543): 0: 584: 72.16
+	Hs
		375131 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		SRC_HUMAN (1-543): 0: 602: 74.22
+	Hs
		374345 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		373735 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		463526 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		374448 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		ABL2_HUMAN (9-543): 6.98e-166: 503: 37.96
+	Hs
		375098 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		374543 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		BTK_HUMAN (4-537): 6.44e-167: 490: 31.35
+	Hs
		373895 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		BTK_HUMAN (4-537): 6.44e-167: 490: 31.35
+	Hs
		375263 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		ABL2_HUMAN (9-543): 6.98e-166: 503: 37.96
+	Hs
		374500 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		EPHA4_HUMAN (4-542): 1.19e-155: 471: 25.00
+	Hs
		373790 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		EPHA3_HUMAN (3-535): 2.06e-156: 473: 25.66
+	Hs
		710629 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		EPHA3_HUMAN (3-535): 2.06e-156: 473: 25.66
+	Hs
		375209 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		EPHA3_HUMAN (3-535): 2.06e-156: 473: 25.66