HitPredict

Interactor 1: APOB (P04114)
Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]
Gene: APOB

Interactor 2: MTP (P55157)
Microsomal triglyceride transfer protein large subunit
Gene: MTTP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.859

The method score is based on:

Property	Details
Experiments	9915855, 26224785, 27487388
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Vit_open_b-sht~Vitellogenin_N, MTP_lip_bd~Vitellogenin_N
Common GO terms	GO:0005788 - endoplasmic reticulum lumen GO:0005829 - cytosol GO:0034374 - low-density lipoprotein particle remodeling GO:0034379 - very-low-density lipoprotein particle assembly GO:0042632 - cholesterol homeostasis and 3 others more... GO:0042953 - lipoprotein transport GO:0051649 - establishment of localization in cell GO:0120020 - cholesterol transfer activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	4563
Hs

1	894

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024