Protein: SWI6
Regulatory protein SWI6 (Cell-cycle box factor subunit SWI6) (MBF subunit P90) (Trans-acting activator of HO endonuclease gene)

Gene: SWI6
Organism: Saccharomyces cerevisiae S288C
Interactions: 135
UniProt ID: P09959

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

488920

SWI4
Regulatory protein SWI4

16

18

Small-scale

0.987

High

488956

MBP1
Transcription factor MBP1

11

18

Small-scale

0.976

High

364246

CDK1
Cyclin-dependent kinase 1

6

4

Small-scale

0.949

High

488916

RAD53
Serine/threonine-protein kinase RAD53

4

6

Small-scale

0.882

High

488988

SLT2
Mitogen-activated protein kinase SLT2/MPK1

2

8

Small-scale

0.825

High

448607

SNF1
Carbon catabolite-derepressing protein kinase

2

4

Small-scale

0.754

High

489018

WHI5
G1-specific transcriptional repressor WHI5

8

1

Small-scale

0.747

High

488927

HRR25
Casein kinase I homolog HRR25

1

6

Small-scale

0.747

High

488909

KIN2
Serine/threonine-protein kinase KIN2

1

5

High-throughput

0.691

High

488965

STB1
Protein STB1

4

1

Small-scale

0.676

High

488979

NRM1
Transcription factor NRM1

4

1

Small-scale

0.672

High

489020

SKM1
Serine/threonine-protein kinase SKM1

1

5

High-throughput

0.647

High

488987

CDC14
Tyrosine-protein phosphatase CDC14

3

20

Small-scale

0.633

High

440817

KIN28
Serine/threonine-protein kinase KIN28

1

3

High-throughput

0.618

High

488915

CSK22
Casein kinase II subunit alpha'

1

13

High-throughput

0.618

High

488930

XPO1
Exportin-1

2

10

Small-scale

0.614

High

489000

POB3
FACT complex subunit POB3

2

1

Small-scale

0.601

High

489008

RSC58
Chromatin structure-remodeling complex protein RSC58

2

1

Small-scale

0.576

High

386530

TBB
Tubulin beta chain

1

9

High-throughput

0.575

High

485981

TBA1
Tubulin alpha-1 chain

1

10

High-throughput

0.575

High

488902

SWI6
Regulatory protein SWI6

1

17

High-throughput

0.575

High

488911

TBP
TATA-box-binding protein

2

2

High-throughput

0.571

High

488928

MCM2
DNA replication licensing factor MCM2

2

8

High-throughput

0.571

High

488959

FDO1
Protein FDO1

2

1

High-throughput

0.571

High

488985

H3
Histone H3

2

15

High-throughput

0.571

High

488997

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

2

3

High-throughput

0.571

High

489013

YL053
Putative uncharacterized protein YLR053C

1

1

Small-scale

0.561

High

488917

VPS15
Serine/threonine-protein kinase VPS15

1

12

High-throughput

0.553

High

488933

SPT16
FACT complex subunit SPT16

2

1

Small-scale

0.549

High

488955

COX23
Cytochrome c oxidase-assembly factor COX23, mitochondrial

1

0

High-throughput

0.518

High

488973

ORC5
Origin recognition complex subunit 5

1

0

Small-scale

0.518

High

488910

CG13
G1/S-specific cyclin CLN3

1

3

Small-scale

0.515

High

488937

BUD2
Inhibitory regulator protein BUD2/CLA2

1

9

High-throughput

0.515

High

488943

MSA2
Putative transcriptional activator MSA2

1

2

High-throughput

0.515

High

488918

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

Small-scale

0.505

High

488974

MSN5
Protein MSN5

1

10

Small-scale

0.481

High

488908

AAKG
5'-AMP-activated protein kinase subunit gamma

1

1

High-throughput

0.479

High

488912

HSC82
ATP-dependent molecular chaperone HSC82

1

13

High-throughput

0.479

High

488924

BUB3
Spindle assembly checkpoint protein BUB3

1

11

High-throughput

0.479

High

488926

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

488941

SPT10
Protein SPT10

1

2

High-throughput

0.479

High

488944

SRL3
Protein SRL3

1

1

Small-scale

0.479

High

488946

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

488947

TBS1
Uncharacterized transcriptional regulatory protein TBS1

1

3

High-throughput

0.479

High

488950

QOR
Probable quinone oxidoreductase

1

2

High-throughput

0.479

High

488952

KPR2
Ribose-phosphate pyrophosphokinase 2

1

3

High-throughput

0.479

High

488953

RFC3
Replication factor C subunit 3

1

3

High-throughput

0.479

High

488954

KPR3
Ribose-phosphate pyrophosphokinase 3

1

3

High-throughput

0.479

High

488960

RFC4
Replication factor C subunit 4

1

3

High-throughput

0.479

High

488961

YRB2
Ran-specific GTPase-activating protein 2

1

4

High-throughput

0.479

High

488962

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

488970

EFM3
Protein-lysine N-methyltransferase EFM3

1

1

High-throughput

0.479

High

488981

ESF2
Pre-rRNA-processing protein ESF2

1

1

High-throughput

0.479

High

488989

CTF4
DNA polymerase alpha-binding protein

1

9

High-throughput

0.479

High

488991

KA120
Importin beta-like protein KAP120

1

3

Small-scale

0.479

High

488996

TAF8
Transcription initiation factor TFIID subunit 8

1

1

High-throughput

0.479

High

488999

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

489007

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

1

High-throughput

0.479

High

489011

MSA1
G1-specific transcription factors activator MSA1

1

2

Small-scale

0.479

High

489014

CMR3
Zinc finger protein CRM3

1

9

High-throughput

0.479

High

489015

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

489016

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

489022

SMC6
Structural maintenance of chromosomes protein 6

1

9

High-throughput

0.479

High

458977

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

488919

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

488921

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

488925

HEM3
Porphobilinogen deaminase

1

0

High-throughput

0.458

High

488929

RIF1
Telomere length regulator protein RIF1

1

0

High-throughput

0.458

High

488935

DRI1
Putative RNA-binding protein involved in heterochromatin assembly

1

0

High-throughput

0.458

High

488939

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.458

High

488942

NNRD
ATP-dependent

1

0

High-throughput

0.458

High

488951

APD1
Actin patches distal protein 1

1

0

High-throughput

0.458

High

488958

PHM8
Phosphate metabolism protein 8

1

0

High-throughput

0.458

High

488967

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

High-throughput

0.458

High

488969

MHO1
MEMO1 family protein MHO1

1

0

High-throughput

0.458

High

488971

BUL1
Ubiquitin ligase-binding protein BUL1

1

0

High-throughput

0.458

High

488972

SOL1
6-phosphogluconolactonase-like protein 1

1

0

High-throughput

0.458

High

488977

RAGCD
GTP-binding protein GTR2

1

0

High-throughput

0.458

High

488980

BUD17
Putative pyridoxal kinase BUD17

1

0

High-throughput

0.458

High

488982

IST1
Vacuolar protein sorting-associated protein IST1

1

0

High-throughput

0.458

High

488995

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.458

High

489001

TAF7
Transcription initiation factor TFIID subunit 7

1

0

High-throughput

0.458

High

489012

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

High-throughput

0.458

High

381363

H2B2
Histone H2B.2

1

12

High-throughput

0.445

High

381803

H4
Histone H4

1

6

High-throughput

0.445

High

394136

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

419553

H2A2
Histone H2A.2

1

8

High-throughput

0.445

High

453363

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

488905

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.445

High

488906

MCM1
Pheromone receptor transcription factor

1

2

High-throughput

0.445

High

488914

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

9

High-throughput

0.445

High

488922

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

488923

RSC6
Chromatin structure-remodeling complex protein RSC6

1

3

High-throughput

0.445

High

488931

BTAF1
TATA-binding protein-associated factor MOT1

1

12

High-throughput

0.445

High

488932

PRP19
Pre-mRNA-processing factor 19

1

12

Small-scale

0.445

High

488934

STH1
Nuclear protein STH1/NPS1

1

7

High-throughput

0.445

High

488936

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

2

High-throughput

0.445

High

488938

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

488948

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

16

High-throughput

0.445

High

488949

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

11

High-throughput

0.445

High

488963

AZF1
Transcription factor AZF1

1

4

High-throughput

0.445

High

488966

RSC8
Chromatin structure-remodeling complex protein RSC8

1

2

High-throughput

0.445

High

488975

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

1

High-throughput

0.445

High

488978

H1
Histone H1

1

1

High-throughput

0.445

High

488984

ACT
Actin

1

20

High-throughput

0.445

High

488992

DIG1
Down-regulator of invasive growth 1

1

1

High-throughput

0.445

High

488993

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

1

High-throughput

0.445

High

488998

RUVB1
RuvB-like protein 1

1

9

High-throughput

0.445

High

489002

ARP9
Actin-like protein ARP9

1

20

High-throughput

0.445

High

489005

RSC3
Chromatin structure-remodeling complex protein RSC3

1

2

High-throughput

0.445

High

489017

ARP8
Actin-like protein ARP8

1

20

High-throughput

0.445

High

489019

RUVB2
RuvB-like protein 2

1

9

High-throughput

0.445

High

489021

H2AZ
Histone H2A.Z

1

7

High-throughput

0.445

High

488986

NUM1
Nuclear migration protein NUM1

1

17

High-throughput

0.439

High

488903

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.437

High

489003

YPQ2
Vacuolar arginine/histidine antiporter YPQ2

1

1

High-throughput

0.437

High

267386

YD13A
Transposon Ty1-DR4 Gag polyprotein

1

0

High-throughput

0.426

High

488964

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

149186

FOB1
DNA replication fork-blocking protein FOB1

1

1

High-throughput

0.407

High

488968

NET1
Nucleolar protein NET1

1

2

High-throughput

0.407

High

488990

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

16

High-throughput

0.407

High

489004

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

19

High-throughput

0.407

High

488904

ADH4
Alcohol dehydrogenase 4

1

0

High-throughput

0.282

High

489010

YO131
Uncharacterized protein YOL131W

1

0

High-throughput

0.282

High

488907

RT13
Small ribosomal subunit protein mS27

1

0

High-throughput

0.249

Low

488913

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.249

Low

488940

SEG2
Eisosome protein SEG2

1

0

High-throughput

0.249

Low

488945

RM10
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.249

Low

488957

FIR1
Factor interacting with REF2

1

0

High-throughput

0.249

Low

488976

YIP5
Protein YIP5

1

0

High-throughput

0.249

Low

488983

YNF8
Vacuolar membrane protein YNL058C

1

0

High-throughput

0.249

Low

488994

YD090
Uncharacterized membrane protein YDR090C

1

0

High-throughput

0.249

Low

489006

FMP45
SUR7 family protein FMP45

1

0

High-throughput

0.249

Low

489009

YO036
Uncharacterized protein YOL036W

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025