HitPredict

Interactor 1: ROA1 (P04256)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (HDP) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: Hnrnpa1

Interactor 2: AAPK1 (P54645)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: Prkaa1

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	24625528
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010628 - positive regulation of gene expression GO:0042149 - cellular response to glucose starvation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 320 Rn			1 559
+	Rn
		871332 PABP1_RAT (6-193): 1.7e-38: 145: 19.05		AAPK1_RAT (1-559): 0: 586: 100.00
+	Rn
		871320 ROA3_RAT (96-190): 2.04e-19: 89.7: 27.37		AAPK1_RAT (1-559): 0: 586: 100.00
+	Rn
		64994 ROA2_RAT (3-106): 1.14e-17: 84.3: 28.85		AAPK1_RAT (1-559): 0: 586: 100.00
+	Rn
		871344 Q9Z0U8_RAT (2-100): 1.13e-17: 83.6: 29.29		AAPK1_RAT (1-559): 0: 586: 100.00
+	Rn
		871334 HNRPD_RAT (2-101): 4.36e-17: 82.8: 31.00		AAPK1_RAT (1-559): 0: 586: 100.00
+	Rn
		871338 Q9QX80_RAT (2-100): 7.45e-17: 80.9: 29.29		AAPK1_RAT (1-559): 0: 586: 100.00
+	Hs
		453436 ROA1_HUMAN (1-186): 5.41e-57: 190: 99.46		MARK2_HUMAN (19-545): 5.78e-146: 441: 30.13
+	Hs
		161966 HNRDL_HUMAN (2-289): 2.83e-57: 192: 32.65		MARK3_HUMAN (2-536): 1.6e-143: 434: 28.57