HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27507811
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 644 Hs			1 522
+	Hs
		409288 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		531648 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		409276 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		PZRN3_HUMAN (55-366): 6.23e-48: 180: 20.31
+	Hs
		301540 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		301560 K2C7_HUMAN (138-505): 3.95e-137: 410: 60.33		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Mm
		1141443 KRT81_MOUSE (79-552): 3.37e-82: 269: 42.35		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Mm
		957023 KRT86_MOUSE (79-495): 2.56e-80: 264: 45.71		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Mm
		1141414 KRT87_MOUSE (77-555): 1.14e-77: 257: 42.74		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Hs
		318801 K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		318774 K2C75_HUMAN (1-579): 4.51e-88: 286: 53.89		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		301586 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		531606 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		TRI58_HUMAN (62-403): 4.42e-43: 161: 11.67
+	Hs
		301525 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		301526 K2C1_HUMAN (1-511): 2.63e-77: 260: 100.00		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		380552 K2C1_HUMAN (1-511): 2.63e-77: 260: 100.00		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		301515 K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		380469 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		531626 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		380682 K2C1_HUMAN (1-511): 2.63e-77: 260: 100.00		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		1062065 K2C72_HUMAN (90-496): 1.88e-73: 247: 61.92		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00