HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	11733534, 10748052, 25921289, 35384245
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 217
+	Rn
		728442 NTRK1_RAT (1-796): 0: 592: 85.61		GRB2_RAT (1-217): 6.71e-76: 229: 100.00
+	Hs
		507939 FGFR1_HUMAN (195-794): 0: 545: 26.34		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924603 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		384213 NTRK1_HUMAN (1-796): 0: 621: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337301 NTRK1_HUMAN (1-796): 0: 621: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		384434 NTRK1_HUMAN (1-796): 0: 621: 100.00		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		384114 NTRK1_HUMAN (1-796): 0: 621: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		384184 NTRK1_HUMAN (1-796): 0: 621: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		384538 NTRK1_HUMAN (1-796): 0: 621: 100.00		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		507989 FGFR1_HUMAN (195-794): 0: 545: 26.34		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		507832 FGFR1_HUMAN (195-794): 0: 545: 26.34		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		507897 FGFR1_HUMAN (195-794): 0: 545: 26.34		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		557707 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		557705 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		508233 FGFR1_HUMAN (195-794): 0: 545: 26.34		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		507829 FGFR1_HUMAN (195-794): 0: 545: 26.34		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		433229 FGFR1_HUMAN (195-794): 0: 545: 26.34		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		508022 FGFR1_HUMAN (195-794): 0: 545: 26.34		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		507818 FGFR1_HUMAN (195-794): 0: 545: 26.34		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		412212 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58