HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: PK3C3 (Q8NEB9)
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)
Gene: PIK3C3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005770 - late endosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 887
+	Hs
		384431 NTRK1_HUMAN (1-796): 0: 621: 100.00		PK3CB_HUMAN (43-886): 0: 586: 21.06
+	Hs
		384430 NTRK1_HUMAN (1-796): 0: 621: 100.00		PK3CA_HUMAN (46-884): 0: 581: 20.30
+	Hs
		787377 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		PK3CB_HUMAN (43-886): 0: 586: 21.06
+	Hs
		128796 NTRK1_HUMAN (1-796): 0: 621: 100.00		P3C2A_HUMAN (112-883): 6.36e-147: 476: 20.64
+	Hs
		607905 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		PK3CA_HUMAN (46-884): 0: 581: 20.30
+	Hs
		384947 NTRK1_HUMAN (1-796): 0: 621: 100.00		Q4LE69_HUMAN (397-886): 5.43e-116: 392: 20.90
+	Hs
		609327 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		Q4LE69_HUMAN (397-886): 5.43e-116: 392: 20.90
+	Hs
		787369 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		PK3CB_HUMAN (43-886): 0: 586: 21.06
+	Hs
		787218 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		PK3CA_HUMAN (46-884): 0: 581: 20.30
+	Hs
		787405 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		PK3CB_HUMAN (43-886): 0: 586: 21.06
+	Hs
		126195 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		PK3CD_HUMAN (43-887): 1.31e-164: 509: 19.08
+	Dm
		448237 INSR_DROME (495-782): 2.38e-63: 233: 40.54		P91634_DROME (113-887): 1.36e-167: 517: 19.15
+	Hs
		135759 NTRK1_HUMAN (1-796): 0: 621: 100.00		P3C2B_HUMAN (31-478): 1.7e-26: 119: 14.66
+	Hs
		435660 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		Q4LE69_HUMAN (397-886): 5.43e-116: 392: 20.90
+	Hs
		435571 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		PI4KA_HUMAN (397-886): 7.91e-116: 391: 20.90
+	Hs
		135765 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		P3C2B_HUMAN (31-478): 1.7e-26: 119: 14.66