HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: KDIS (Q9ULH0)
Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)
Gene: KIDINS220

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	25921289, 11150334, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005770 - late endosome GO:0010976 - positive regulation of neuron projection development GO:0032991 - protein-containing complex GO:0038180 - nerve growth factor signaling pathway GO:1990090 - cellular response to nerve growth factor stimulus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 1771
+	Hs
		1083907 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		1081644 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Rn
		728451 NTRK1_RAT (1-796): 0: 592: 85.61		KDIS_RAT (13-1771): 0: 2556: 93.24
+	Hs
		608184 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		601612 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		665439 EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		872504 EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36		KDIS_HUMAN (13-1771): 0: 2634: 100.00
+	Hs
		507831 FGFR1_HUMAN (195-794): 0: 545: 26.34		ANK1_HUMAN (96-531): 5.46e-92: 334: 20.00
+	Hs
		257545 NTRK1_HUMAN (1-796): 0: 621: 100.00		ANR17_HUMAN (261-522): 2.37e-53: 209: 19.32
+	Hs
		384666 NTRK1_HUMAN (1-796): 0: 621: 100.00		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Hs
		507971 FGFR1_HUMAN (195-794): 0: 545: 26.34		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		1021409 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50
+	Hs
		507954 FGFR1_HUMAN (195-794): 0: 545: 26.34		ANK2_HUMAN (3-233): 5.93e-53: 208: 25.11
+	Hs
		385170 NTRK1_HUMAN (1-796): 0: 621: 100.00		ANR44_HUMAN (1-103): 1.28e-18: 94.8: 19.63
+	Hs
		166874 NTRK1_HUMAN (1-796): 0: 621: 100.00		ANR28_HUMAN (411-503): 1.03e-09: 65.9: 6.45
+	Hs
		434183 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		ANK3_HUMAN (206-542): 1.55e-67: 256: 18.50