HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: S10A8 (P05109)
Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)
Gene: S100A8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	16169070, 32807901, 35654045
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	S_100~TAD2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006914 - autophagy GO:0008270 - zinc ion binding GO:2001244 - positive regulation of intrinsic apoptotic signaling pathway
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 93
+	Hs
		387043 P53_HUMAN (1-393): 0: 619: 100.00		HORN_HUMAN (2-89): 7.34e-30: 112: 25.00
+	Hs
		386104 P53_HUMAN (1-393): 0: 619: 100.00		S10A1_HUMAN (1-90): 8.66e-33: 110: 36.17
+	Hs
		386185 P53_HUMAN (1-393): 0: 619: 100.00		S10AB_HUMAN (2-93): 1.23e-31: 108: 26.04
+	Hs
		386137 P53_HUMAN (1-393): 0: 619: 100.00		S10A4_HUMAN (1-93): 4.07e-31: 106: 27.84
+	Hs
		386132 P53_HUMAN (1-393): 0: 619: 100.00		S100P_HUMAN (2-92): 1.25e-30: 105: 35.79
+	Hs
		386155 P53_HUMAN (1-393): 0: 619: 100.00		S10A2_HUMAN (1-92): 1.72e-29: 102: 26.04
+	Hs
		386192 P53_HUMAN (1-393): 0: 619: 100.00		S10A3_HUMAN (1-90): 1.52e-28: 100: 22.34
+	Hs
		386865 P53_HUMAN (1-393): 0: 619: 100.00		FILA2_HUMAN (2-89): 4.61e-25: 99.1: 29.35
+	Hs
		386412 P53_HUMAN (1-393): 0: 619: 100.00		S10AA_HUMAN (1-93): 5.15e-28: 98.7: 25.77
+	Hs
		380714 P53_HUMAN (1-393): 0: 619: 100.00		S100B_HUMAN (2-89): 3.95e-27: 96.4: 32.61
+	Hs
		385924 P53_HUMAN (1-393): 0: 619: 100.00		S10A6_HUMAN (1-88): 9.59e-27: 95.3: 24.44
+	Hs
		386512 P53_HUMAN (1-393): 0: 619: 100.00		S10AC_HUMAN (2-89): 4.03e-26: 93.7: 38.04
+	Hs
		386191 P53_HUMAN (1-393): 0: 619: 100.00		S10A5_HUMAN (1-91): 7.64e-25: 90.6: 29.35
+	Hs
		387288 P53_HUMAN (1-393): 0: 619: 100.00		S10AG_HUMAN (3-92): 2.69e-23: 87.2: 25.26
+	Hs
		387371 P53_HUMAN (1-393): 0: 619: 100.00		S10AD_HUMAN (2-80): 4.4e-21: 81.4: 23.75