HitPredict

Interactor 1: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Interactor 2: WWC2 (Q6AWC2)
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
Gene: WWC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24682284
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 672 Hs			1 1192
+	Hs
		566504 KPCA_HUMAN (1-672): 0: 794: 100.00		WWC3_HUMAN (6-1192): 0: 836: 43.32
+	Hs
		566424 KPCA_HUMAN (1-672): 0: 794: 100.00		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		408626 KPCB_HUMAN (1-664): 0: 749: 78.89		SYT6_HUMAN (569-973): 7.69e-110: 355: 11.89
+	Hs
		566492 KPCA_HUMAN (1-672): 0: 794: 100.00		WWOX_HUMAN (5-198): 5.51e-47: 176: 21.11
+	Hs
		784039 KPCI_HUMAN (22-86): 8.63e-12: 70.1: 43.08		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		983870 KPCZ_HUMAN (22-98): 3.2e-11: 68.6: 34.44		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		566484 KPCA_HUMAN (1-672): 0: 794: 100.00		SMUF1_HUMAN (40-194): 1.56e-14: 80.8: 16.49
+	Hs
		397181 KPCG_HUMAN (1-670): 0: 706: 68.94		SMUF1_HUMAN (40-194): 1.56e-14: 80.8: 16.49
+	Dm
		54663 APKC_DROME (22-86): 6.73e-13: 73.9: 44.62		KIBRA_DROME (8-1190): 0: 661: 30.31
+	Hs
		808324 AKT3_HUMAN (283-660): 6.86e-156: 460: 40.46		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Hs
		681731 AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Xl
		1151478 SGK1A_XENLA (255-661): 9.69e-154: 453: 38.04		Q6GMD5_XENLA (58-182): 9.76e-13: 75: 20.00
+	Hs
		116984 SGK1_HUMAN (255-661): 1.16e-153: 452: 38.85		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Hs
		1299664 AKT3_HUMAN (283-660): 6.86e-156: 460: 40.46		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Hs
		681988 AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Hs
		117024 SGK1_HUMAN (255-661): 1.16e-153: 452: 38.85		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Dm
		54672 APKC_DROME (22-86): 6.73e-13: 73.9: 44.62		Q9W2L2_DROME (5-310): 9.38e-66: 245: 19.57
+	Hs
		784093 KPCI_HUMAN (22-86): 8.63e-12: 70.1: 43.08		SMUF1_HUMAN (40-194): 1.56e-14: 80.8: 16.49