HitPredict - High confidence protein-protein interactions

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	8083962, 38580884, 20871633, 34591642
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 15 others more... GO:0006355 - regulation of DNA-templated transcription GO:0007265 - Ras protein signal transduction GO:0014009 - glial cell proliferation GO:0016605 - PML body GO:0030308 - negative regulation of cell growth GO:0031625 - ubiquitin protein ligase binding GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051276 - chromosome organization GO:0051402 - neuron apoptotic process GO:0051726 - regulation of cell cycle GO:0060253 - negative regulation of glial cell proliferation GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0071466 - cellular response to xenobiotic stimulus GO:0097718 - disordered domain specific binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	928

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024