HitPredict - High confidence protein-protein interactions

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.759

Property	Details
Experiments	15375079, 11080164, 20972456, 21057547, 16007146, 22869143, 12915590, 11025664, 38580884, 14976551
Identification Methods	affinity chromatography technology, pull down, enzymatic study, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm and 22 others more... GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0006606 - protein import into nucleus GO:0006977 - DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0008270 - zinc ion binding GO:0008285 - negative regulation of cell population proliferation GO:0010332 - response to gamma radiation GO:0016363 - nuclear matrix GO:0016605 - PML body GO:0030308 - negative regulation of cell growth GO:0031625 - ubiquitin protein ligase binding GO:0032211 - negative regulation of telomere maintenance via telomerase GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043153 - entrainment of circadian clock by photoperiod GO:0045892 - negative regulation of DNA-templated transcription GO:0046982 - protein heterodimerization activity GO:0050821 - protein stabilization GO:0051726 - regulation of cell cycle GO:0065003 - protein-containing complex assembly GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0090398 - cellular senescence
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	882

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024