Protein: NFL
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)

Gene: NFL, NEFL
Organism: Homo sapiens
Interactions: 240
UniProt ID: P07196

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0005200 - structural constituent of cytoskeleton
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005882 - intermediate filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

451100

VIME
Vimentin

9

20

High-throughput

0.974

High

451099

NFM
Neurofilament medium polypeptide

9

20

High-throughput

0.969

High

451118

DESM
Desmin

6

20

High-throughput

0.946

High

451115

GFAP
Glial fibrillary acidic protein

5

20

High-throughput

0.931

High

451272

SYNCI
Syncoilin

3

20

High-throughput

0.866

High

451110

NFH
Neurofilament heavy polypeptide

3

20

Small-scale

0.855

High

436765

K1C18
Keratin, type I cytoskeletal 18

2

20

High-throughput

0.793

High

451120

K1C15
Keratin, type I cytoskeletal 15

2

20

High-throughput

0.791

High

451113

K1C13
Keratin, type I cytoskeletal 13

1

20

High-throughput

0.698

High

385036

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.691

High

451102

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.691

High

451129

NEST
Nestin

1

20

High-throughput

0.691

High

451163

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.691

High

451194

K1C27
Keratin, type I cytoskeletal 27

1

20

High-throughput

0.691

High

451264

K1C23
Keratin, type I cytoskeletal 23

1

20

High-throughput

0.691

High

451252

NECD
Necdin

3

7

High-throughput

0.667

High

451101

K1C19
Keratin, type I cytoskeletal 19

1

20

High-throughput

0.665

High

451157

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.665

High

288336

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

3

16

High-throughput

0.654

High

451304

NDK7
Nucleoside diphosphate kinase homolog 7

3

3

High-throughput

0.654

High

451162

RABE1
Rab GTPase-binding effector protein 1

2

11

High-throughput

0.628

High

451188

FA83H
Protein FAM83H

2

12

High-throughput

0.628

High

451196

DPP9
Dipeptidyl peptidase 9

2

1

High-throughput

0.628

High

451224

BICD2
Protein bicaudal D homolog 2

2

20

High-throughput

0.628

High

451235

RSPRY
RING finger and SPRY domain-containing protein 1

2

6

High-throughput

0.628

High

451237

BICD1
Protein bicaudal D homolog 1

2

20

High-throughput

0.628

High

451111

SKIL
Ski-like protein

2

2

High-throughput

0.628

High

451124

S100P
Protein S100-P

2

3

High-throughput

0.621

High

451168

PKN1
Serine/threonine-protein kinase N1

2

12

Small-scale

0.618

High

437056

K2C8
Keratin, type II cytoskeletal 8

1

20

High-throughput

0.618

High

451206

CCD13
Coiled-coil domain-containing protein 13

2

12

High-throughput

0.606

High

451220

SMYD1
Histone-lysine N-methyltransferase SMYD1

2

1

High-throughput

0.606

High

451274

NEK6
Serine/threonine-protein kinase Nek6

2

15

High-throughput

0.606

High

451132

MECP2
Methyl-CpG-binding protein 2

2

11

High-throughput

0.601

High

156850

CTRO
Citron Rho-interacting kinase

2

20

High-throughput

0.584

High

451119

RL7
Large ribosomal subunit protein uL30

2

1

High-throughput

0.584

High

451229

TSC1
Hamartin

1

20

Small-scale

0.573

High

451182

PPR18
Phostensin

1

18

High-throughput

0.573

High

451289

RHG23
Rho GTPase-activating protein 23

2

11

High-throughput

0.571

High

451259

KIFC3
Kinesin-like protein KIFC3

2

16

High-throughput

0.559

High

421309

A4
Amyloid-beta precursor protein

1

7

Small-scale

0.554

High

451133

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.549

High

249082

DSCAM
Cell adhesion molecule DSCAM

1

7

High-throughput

0.541

High

451131

FXR1
RNA-binding protein FXR1

1

14

High-throughput

0.541

High

451166

ITSN1
Intersectin-1

1

20

High-throughput

0.541

High

451185

KLC3
Kinesin light chain 3

1

8

High-throughput

0.541

High

451260

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

14

High-throughput

0.541

High

174900

SC16A
Protein transport protein Sec16A

1

5

High-throughput

0.536

High

451116

IDE
Insulin-degrading enzyme

1

11

High-throughput

0.536

High

451126

HD
Huntingtin

1

9

High-throughput

0.536

High

451144

ANK2
Ankyrin-2

1

15

High-throughput

0.536

High

451156

MAP7
Ensconsin

1

20

High-throughput

0.536

High

451226

TBCK
TBC domain-containing protein kinase-like protein

1

10

High-throughput

0.536

High

451230

CDKL2
Cyclin-dependent kinase-like 2

1

5

High-throughput

0.536

High

105134

APRIO
Alternative prion protein

2

7

High-throughput

0.533

High

451207

TEX11
Testis-expressed protein 11

2

2

High-throughput

0.533

High

451143

ECT2L
Epithelial cell-transforming sequence 2 oncogene-like

2

19

High-throughput

0.521

High

451227

DEP1B
DEP domain-containing protein 1B

2

8

High-throughput

0.521

High

451104

CC172
Coiled-coil domain-containing protein 172

1

0

High-throughput

0.518

High

451138

1433G
14-3-3 protein gamma

1

20

High-throughput

0.515

High

347469

BAG3
BAG family molecular chaperone regulator 3

1

6

High-throughput

0.515

High

451114

ANXA8
Annexin A8

1

3

High-throughput

0.515

High

451122

VATB2
V-type proton ATPase subunit B, brain isoform

1

2

High-throughput

0.515

High

451137

VSX2
Visual system homeobox 2

1

3

High-throughput

0.515

High

451140

DYLT1
Dynein light chain Tctex-type 1

1

2

High-throughput

0.515

High

451155

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

18

High-throughput

0.515

High

451158

LASP1
LIM and SH3 domain protein 1

1

15

High-throughput

0.515

High

451160

MLC1
Membrane protein MLC1

1

1

High-throughput

0.515

High

451176

DCAF8
DDB1- and CUL4-associated factor 8

1

8

High-throughput

0.515

High

451178

TASO2
Protein TASOR 2

1

18

High-throughput

0.515

High

451179

TUT7
Terminal uridylyltransferase 7

1

6

High-throughput

0.515

High

451187

NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

1

2

High-throughput

0.515

High

451191

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

3

High-throughput

0.515

High

451192

G2E3
G2/M phase-specific E3 ubiquitin-protein ligase

1

3

High-throughput

0.515

High

451202

CRLF3
Cytokine receptor-like factor 3

1

1

High-throughput

0.515

High

451204

MSRB3
Methionine-R-sulfoxide reductase B3

1

1

High-throughput

0.515

High

451213

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.515

High

451215

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

6

High-throughput

0.515

High

451221

PPTC7
Protein phosphatase PTC7 homolog

1

1

High-throughput

0.515

High

451222

FANK1
Fibronectin type 3 and ankyrin repeat domains protein 1

1

9

High-throughput

0.515

High

451223

RHPN1
Rhophilin-1

1

11

High-throughput

0.515

High

451239

MY15B
Unconventional myosin-XVB

1

11

High-throughput

0.515

High

451246

ZN641
Zinc finger protein 641

1

8

High-throughput

0.515

High

451250

EYA3
Protein phosphatase EYA3

1

1

High-throughput

0.515

High

451265

ZN436
Zinc finger protein 436

1

5

High-throughput

0.515

High

451271

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

8

High-throughput

0.515

High

451275

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

5

High-throughput

0.515

High

451282

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.515

High

451290

PAK5
Serine/threonine-protein kinase PAK 5

1

12

High-throughput

0.515

High

451291

RCOR3
REST corepressor 3

1

5

High-throughput

0.515

High

451292

GCP4
Gamma-tubulin complex component 4

1

7

High-throughput

0.515

High

451297

CLC11
C-type lectin domain family 11 member A

1

1

High-throughput

0.515

High

451303

ASB3
Ankyrin repeat and SOCS box protein 3

1

19

High-throughput

0.515

High

451149

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

16

High-throughput

0.508

High

451211

PIAS4
E3 SUMO-protein ligase PIAS4

1

8

High-throughput

0.508

High

451276

BRD7
Bromodomain-containing protein 7

1

5

High-throughput

0.508

High

451117

BRAF
Serine/threonine-protein kinase B-raf

1

7

High-throughput

0.506

High

451153

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

1

3

Small-scale

0.506

High

451109

MTAP2
Microtubule-associated protein 2

1

20

Small-scale

0.501

High

451154

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

12

Small-scale

0.501

High

451136

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.494

High

451147

GOGA2
Golgin subfamily A member 2

1

20

High-throughput

0.494

High

451121

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

1

0

High-throughput

0.493

High

451151

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

High-throughput

0.493

High

451184

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.493

High

451195

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.493

High

451201

KRA81
Keratin-associated protein 8-1

1

0

High-throughput

0.493

High

451205

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.493

High

451218

SMIP4
Sperm-associated microtubule inner protein 4

1

0

High-throughput

0.493

High

451247

RBM14
RNA-binding protein 14

1

0

High-throughput

0.493

High

451254

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.493

High

451257

PELO
Protein pelota homolog

1

0

High-throughput

0.493

High

451169

CF184
Cilia- and flagella-associated protein 184

1

3

High-throughput

0.489

High

451301

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

20

High-throughput

0.489

High

169392

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

16

High-throughput

0.481

High

246399

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.481

High

451174

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

20

High-throughput

0.481

High

451177

MYOME
Myomegalin

1

18

High-throughput

0.481

High

451208

CE57L
Centrosomal protein CEP57L1

1

7

High-throughput

0.481

High

451212

TXLNB
Beta-taxilin

1

20

High-throughput

0.481

High

451231

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.481

High

451249

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

1

13

High-throughput

0.481

High

451262

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.481

High

65898

RHG42
Rho GTPase-activating protein 42

1

10

High-throughput

0.479

High

135021

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

5

High-throughput

0.479

High

137917

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

12

High-throughput

0.479

High

222641

PRC1
Protein regulator of cytokinesis 1

1

12

High-throughput

0.479

High

240505

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.479

High

271828

OBSL1
Obscurin-like protein 1

1

15

High-throughput

0.479

High

330575

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

384608

CRYAB
Alpha-crystallin B chain

1

9

High-throughput

0.479

High

451103

HXB5
Homeobox protein Hox-B5

1

11

High-throughput

0.479

High

451105

SCHI1
Schwannomin-interacting protein 1

1

1

High-throughput

0.479

High

451106

ANDR
Androgen receptor

1

19

Small-scale

0.479

High

451108

MCF2
Proto-oncogene DBL

1

10

High-throughput

0.479

High

451112

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

451125

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

Small-scale

0.479

High

451130

TSC2
Tuberin

1

8

Small-scale

0.479

High

451135

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

17

High-throughput

0.479

High

451141

BASP1
Brain acid soluble protein 1

1

12

High-throughput

0.479

High

451142

PSG9
Pregnancy-specific beta-1-glycoprotein 9

1

4

High-throughput

0.479

High

451148

FOXO1
Forkhead box protein O1

1

2

High-throughput

0.479

High

451161

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

451167

EZH2
Histone-lysine N-methyltransferase EZH2

1

11

High-throughput

0.479

High

451199

ARHGP
Rho guanine nucleotide exchange factor 25

1

9

High-throughput

0.479

High

451200

SKAP1
Src kinase-associated phosphoprotein 1

1

18

High-throughput

0.479

High

451203

ARHGJ
Rho guanine nucleotide exchange factor 19

1

19

High-throughput

0.479

High

451210

RHG24
Rho GTPase-activating protein 24

1

11

High-throughput

0.479

High

451216

NGEF
Ephexin-1

1

19

High-throughput

0.479

High

451228

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

451243

FGD4
FYVE, RhoGEF and PH domain-containing protein 4

1

20

High-throughput

0.479

High

451253

ANM1
Protein arginine N-methyltransferase 1

1

9

High-throughput

0.479

High

451267

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

451269

GAN
Gigaxonin

1

15

High-throughput

0.479

High

451270

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

451273

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

451277

ANLN
Anillin

1

12

High-throughput

0.479

High

451279

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

451288

GMIP
GEM-interacting protein

1

13

High-throughput

0.479

High

451293

XPO7
Exportin-7

1

9

High-throughput

0.479

High

451296

CC14A
Dual specificity protein phosphatase CDC14A

1

1

High-throughput

0.479

High

451307

SETBP
SET-binding protein

1

1

High-throughput

0.479

High

4775

A0A1B0GWI1
Coiled-coil domain containing 196

1

3

High-throughput

0.470

High

193839

ZSC9
Zinc finger and SCAN domain-containing protein 9

1

12

High-throughput

0.470

High

217041

MS18B
Protein Mis18-beta

1

6

High-throughput

0.470

High

302136

NEBL
Nebulette

1

20

High-throughput

0.470

High

451128

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

2

High-throughput

0.470

High

451152

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.470

High

451165

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

10

High-throughput

0.470

High

451170

ZN829
Zinc finger protein 829

1

7

High-throughput

0.470

High

451172

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

3

High-throughput

0.470

High

451173

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

4

High-throughput

0.470

High

451180

TTC23
Tetratricopeptide repeat protein 23

1

7

High-throughput

0.470

High

451181

ZNF57
Zinc finger protein 57

1

4

High-throughput

0.470

High

451186

ELAP1
Endosome/lysosome-associated apoptosis and autophagy regulator 1

1

1

High-throughput

0.470

High

451189

K0408
Uncharacterized protein KIAA0408

1

3

High-throughput

0.470

High

451193

ZN572
Zinc finger protein 572

1

9

High-throughput

0.470

High

451197

TAD2B
Transcriptional adapter 2-beta

1

1

High-throughput

0.470

High

451198

Q86V28
AP-1 complex subunit gamma

1

2

High-throughput

0.470

High

451225

TCP1L
T-complex protein 10A homolog 1

1

3

High-throughput

0.470

High

451244

ZN488
Zinc finger protein 488

1

1

High-throughput

0.470

High

451278

ZN302
Zinc finger protein 302

1

4

High-throughput

0.470

High

451294

ZN180
Zinc finger protein 180

1

3

High-throughput

0.470

High

451240

ANM6
Protein arginine N-methyltransferase 6

1

9

High-throughput

0.464

High

124199

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

451145

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

451232

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

451233

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

451284

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

247213

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

11

High-throughput

0.457

High

451139

RAN
GTP-binding nuclear protein Ran

1

3

High-throughput

0.457

High

451150

HSPB3
Heat shock protein beta-3

1

9

High-throughput

0.457

High

451248

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.457

High

451280

PICK1
PRKCA-binding protein

1

1

High-throughput

0.457

High

451281

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

451295

TNIK
TRAF2 and NCK-interacting protein kinase

1

10

High-throughput

0.457

High

254741

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.445

High

404622

PRIO
Major prion protein

1

1

High-throughput

0.445

High

451107

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

451134

TERA
Transitional endoplasmic reticulum ATPase

1

9

High-throughput

0.445

High

451175

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

451219

POC5
Centrosomal protein POC5

1

2

High-throughput

0.445

High

451245

CEP63
Centrosomal protein of 63 kDa

1

15

High-throughput

0.445

High

451123

CCNC
Cyclin-C

1

4

High-throughput

0.439

High

451217

USBP1
Harmonin-binding protein USHBP1

1

15

High-throughput

0.439

High

451266

ENKD1
Enkurin domain-containing protein 1

1

3

High-throughput

0.439

High

451238

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

377918

TNFA
Tumor necrosis factor

1

4

High-throughput

0.437

High

451190

COX15
Heme A synthase COX15

1

2

High-throughput

0.437

High

451263

RHBT2
Rho-related BTB domain-containing protein 2

1

15

High-throughput

0.437

High

451268

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.437

High

451285

OCAD1
OCIA domain-containing protein 1

1

2

High-throughput

0.437

High

451286

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

1

High-throughput

0.437

High

451306

MTCH2
Mitochondrial carrier homolog 2

1

3

High-throughput

0.437

High

451183

Q6P2R3
C6orf182 protein

1

7

High-throughput

0.417

High

87304

OSCRI
SCRIB overlapping open reading frame protein

1

2

High-throughput

0.407

High

451127

EAA2
Excitatory amino acid transporter 2

1

1

High-throughput

0.407

High

451251

ZBT18
Zinc finger and BTB domain-containing protein 18

1

6

High-throughput

0.407

High

451298

ITM2B
Integral membrane protein 2B

1

9

High-throughput

0.407

High

451234

RMC1
Regulator of MON1-CCZ1 complex

2

0

High-throughput

0.328

High

451256

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.282

High

60673

A2RU56
LOC401296 protein

1

0

High-throughput

0.268

Low

451171

CP100
Cilia- and flagella-associated protein 100

1

0

High-throughput

0.268

Low

451209

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

451241

PGRP3
Peptidoglycan recognition protein 3

1

0

High-throughput

0.268

Low

451242

CH048
Uncharacterized protein C8orf48

1

0

High-throughput

0.268

Low

451255

SYT3
Synaptotagmin-3

1

0

High-throughput

0.268

Low

451287

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

1

0

High-throughput

0.268

Low

451305

RAI2
Retinoic acid-induced protein 2

1

0

High-throughput

0.268

Low

451214

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

451159

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

451164

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.249

Low

451258

PHAF1
Phagosome assembly factor 1

1

0

High-throughput

0.249

Low

451261

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

451302

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low

451146

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.232

Low

451236

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.232

Low

451283

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low

451299

S45A1
Proton-associated sugar transporter A

1

0

High-throughput

0.232

Low

451300

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025