HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: SENP1 (Q9P0U3)
Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)
Gene: SENP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	24927568, 29568061, 34079125, 32344865, 22412018
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031965 - nuclear membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 644
+	Hs
		634674 LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45		SENP1_HUMAN (1-644): 0: 665: 100.00
+	Hs
		386254 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		SENP2_HUMAN (139-644): 1.49e-142: 429: 33.46
+	Dr
		74784 B3DKC5_DANRE (9-597): 1.57e-53: 196: 64.92		E7F9B8_DANRE (3-644): 3.14e-164: 489: 45.56
+	Hs
		634646 LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45		SENP2_HUMAN (139-644): 1.49e-142: 429: 33.46
+	Hs
		474984 VIME_HUMAN (27-389): 3.96e-31: 129: 28.93		SENP3_HUMAN (93-643): 1.96e-107: 338: 22.63
+	Hs
		386205 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		SENP6_HUMAN (271-642): 2.25e-19: 95.1: 14.98
+	Mm
		628514 VIME_MOUSE (27-394): 8.73e-32: 130: 29.35		SENP7_MOUSE (419-643): 3.88e-48: 184: 18.61
+	Hs
		474937 VIME_HUMAN (27-389): 3.96e-31: 129: 28.93		SENP7_HUMAN (386-643): 1.6e-46: 179: 17.38