HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PPP5 (P53041)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	14764652
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 499
+	Hs
		395870 ESR1_HUMAN (1-595): 0: 599: 100.00		PP2AA_HUMAN (190-481): 9.42e-168: 477: 40.88
+	Hs
		395838 ESR1_HUMAN (1-595): 0: 599: 100.00		PP2AB_HUMAN (182-485): 4.52e-163: 465: 38.69
+	Hs
		395609 ESR1_HUMAN (1-595): 0: 599: 100.00		PP1G_HUMAN (196-486): 6.61e-154: 442: 37.12
+	Hs
		395815 ESR1_HUMAN (1-595): 0: 599: 100.00		PP1A_HUMAN (196-481): 7.04e-154: 442: 37.98
+	Mm
		625741 ESR1_MOUSE (1-595): 0: 570: 88.98		PP1G_MOUSE (196-486): 4.51e-154: 443: 37.12
+	Hs
		916695 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		PPP5_HUMAN (1-499): 0: 577: 100.00
+	Hs
		403933 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		PPP5_HUMAN (1-499): 0: 577: 100.00
+	Hs
		467777 MCR_HUMAN (21-554): 3.99e-103: 335: 22.01		PPP5_HUMAN (1-499): 0: 577: 100.00
+	Hs
		977553 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		PP2AB_HUMAN (182-485): 4.52e-163: 465: 38.69
+	Hs
		968397 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		PP1B_HUMAN (196-490): 1.25e-154: 444: 35.28
+	Hs
		786755 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		PP1G_HUMAN (196-486): 6.61e-154: 442: 37.12
+	Hs
		967889 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		PP1A_HUMAN (196-481): 7.04e-154: 442: 37.98
+	Hs
		343253 ERR2_HUMAN (92-547): 4.32e-116: 354: 34.86		PP2AA_HUMAN (190-481): 9.42e-168: 477: 40.88
+	Hs
		343247 ERR2_HUMAN (92-547): 4.32e-116: 354: 34.86		PP2AB_HUMAN (182-485): 4.52e-163: 465: 38.69
+	Hs
		467778 MCR_HUMAN (21-554): 3.99e-103: 335: 22.01		PP1A_HUMAN (196-481): 7.04e-154: 442: 37.98
+	Hs
		442904 PRGR_HUMAN (183-508): 6.95e-44: 170: 32.14		PPP5_HUMAN (1-499): 0: 577: 100.00
+	Hs
		519869 ANDR_HUMAN (172-455): 8.99e-37: 148: 30.16		PPP5_HUMAN (1-499): 0: 577: 100.00
+	Hs
		519930 ANDR_HUMAN (172-455): 8.99e-37: 148: 30.16		PP2AA_HUMAN (190-481): 9.42e-168: 477: 40.88
+	Hs
		519902 ANDR_HUMAN (172-455): 8.99e-37: 148: 30.16		PP1B_HUMAN (196-490): 1.25e-154: 444: 35.28
+	Hs
		519901 ANDR_HUMAN (172-455): 8.99e-37: 148: 30.16		PP1A_HUMAN (196-481): 7.04e-154: 442: 37.98