HitPredict

Interactor 1: S10A8 (P05109)
Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)
Gene: S100A8

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	26402096, 35063084
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006919 - activation of cysteine-type endopeptidase activity involved in apoptotic process and 1 others more... GO:0008017 - microtubule binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 93 Hs			1 758
+	Hs
		497264 HORN_HUMAN (2-89): 7.34e-30: 112: 25.00		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496312 S10A1_HUMAN (1-90): 8.66e-33: 110: 36.17		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		416341 S10A9_HUMAN (2-88): 5.5e-28: 99.1: 26.09		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497147 FILA2_HUMAN (2-89): 4.61e-25: 99.1: 29.35		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496690 S10AA_HUMAN (1-93): 5.15e-28: 98.7: 25.77		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		380723 S100B_HUMAN (2-89): 3.95e-27: 96.4: 32.61		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		416558 S10A6_HUMAN (1-88): 9.59e-27: 95.3: 24.44		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497435 S10AG_HUMAN (3-92): 2.69e-23: 87.2: 25.26		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496287 FILA_HUMAN (2-90): 4.67e-19: 81.8: 27.96		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		497487 S10AD_HUMAN (2-80): 4.4e-21: 81.4: 23.75		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		152595 S10A2_HUMAN (1-92): 1.72e-29: 102: 26.04		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Bt
		361268 S100B_BOVIN (2-89): 1.09e-27: 98: 32.61		TAU_BOVIN (1-291): 3.66e-12: 71.3: 40.00