HitPredict

Interactor 1: ITB1 (P05556)
Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)
Gene: ITGB1

Interactor 2: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.54 0.60 0.571

The method score is based on:

Property Details
Experiments 12114318, 18931684
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0009897 - external side of plasma membrane
GO:0015026 - coreceptor activity
and 7 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 798
Hs

1 1356
+ Hs
+ Hs
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+ Dm
+ Mm
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024