HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	35384245, 34273398
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 365 Hs			1 1620
+	Hs
		521047 HLAC_HUMAN (1-364): 5.11e-153: 436: 80.27		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		409223 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		RET_HUMAN (804-1477): 5.87e-139: 460: 23.15
+	Hs
		409262 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		FGFR2_HUMAN (952-1433): 1.46e-122: 406: 25.24
+	Hs
		409218 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		INSR_HUMAN (973-1436): 1e-112: 392: 34.25
+	Hs
		409224 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77
+	Hs
		179591 HLAB_HUMAN (1-362): 3.11e-160: 454: 85.64		MUSK_HUMAN (983-1391): 1.78e-119: 399: 29.98
+	Rn
		580486 Q31255_RAT (4-364): 3.04e-160: 455: 63.84		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Hs
		179595 HLAC_HUMAN (1-364): 5.11e-153: 436: 80.27		MUSK_HUMAN (983-1391): 1.78e-119: 399: 29.98
+	Hs
		465377 HLAC_HUMAN (1-364): 5.11e-153: 436: 80.27		IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77
+	Rn
		67725 A7LNF8_RAT (25-329): 7.5e-135: 388: 66.89		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Hs
		409214 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		409396 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		409236 HLAA_HUMAN (1-365): 2.04e-180: 506: 100.00		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Mm
		380231 HA1B_MOUSE (4-365): 3.72e-163: 462: 67.22		FES_MOUSE (1101-1383): 3.22e-59: 222: 41.72
+	Hs
		520859 HLAC_HUMAN (1-364): 5.11e-153: 436: 80.27		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		719713 HLAF_HUMAN (4-348): 8.58e-144: 412: 80.29		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03