Protein: HLAF
HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F)

Gene: HLAF, HLA-F
Organism: Homo sapiens
Interactions: 94
UniProt ID: P30511

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002476 - antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002477 - antigen processing and presentation of exogenous peptide antigen via MHC class Ib
GO:0002486 - antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568039

HLAE
HLA class I histocompatibility antigen, alpha chain E

4

16

Small-scale

0.908

High

520757

HLAC
HLA class I histocompatibility antigen, C alpha chain

3

16

High-throughput

0.861

High

719707

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

3

20

Small-scale

0.847

High

719702

KI3L2
Killer cell immunoglobulin-like receptor 3DL2

2

20

Small-scale

0.825

High

607348

HLAG
HLA class I histocompatibility antigen, alpha chain G

2

16

High-throughput

0.811

High

719703

KI2S4
Killer cell immunoglobulin-like receptor 2DS4

2

20

Small-scale

0.806

High

719712

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

2

20

Small-scale

0.802

High

719701

KI3L1
Killer cell immunoglobulin-like receptor 3DL1

2

20

Small-scale

0.789

High

719720

CEA21
Cell adhesion molecule CEACAM21

2

6

High-throughput

0.789

High

719700

GRIA3
Glutamate receptor 3

2

0

High-throughput

0.770

High

231035

VEGFD
Vascular endothelial growth factor D

1

1

High-throughput

0.691

High

282827

CRLF1
Cytokine receptor-like factor 1

1

4

High-throughput

0.691

High

380617

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

19

High-throughput

0.691

High

438872

CD1A
T-cell surface glycoprotein CD1a

1

17

High-throughput

0.691

High

567802

PRG2
Bone marrow proteoglycan

1

10

High-throughput

0.691

High

664031

PRTN3
Myeloblastin

1

7

High-throughput

0.691

High

705946

CD1B
T-cell surface glycoprotein CD1b

1

17

High-throughput

0.691

High

719708

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

18

High-throughput

0.691

High

719719

CL12B
C-type lectin domain family 12 member B

1

20

High-throughput

0.691

High

719725

TM11B
Transmembrane protease serine 11B

1

12

High-throughput

0.691

High

719730

CLC2B
C-type lectin domain family 2 member B

1

20

High-throughput

0.691

High

719737

LR37B
Leucine-rich repeat-containing protein 37B

1

2

High-throughput

0.691

High

719754

CLC2D
C-type lectin domain family 2 member D

1

20

High-throughput

0.691

High

719755

BTNL2
Butyrophilin-like protein 2

1

6

High-throughput

0.691

High

719758

CAH14
Carbonic anhydrase 14

1

2

High-throughput

0.691

High

719759

CLC4E
C-type lectin domain family 4 member E

1

13

High-throughput

0.691

High

719760

CLC4A
C-type lectin domain family 4 member A

1

16

High-throughput

0.691

High

719739

SIRPD
Signal-regulatory protein delta

1

0

High-throughput

0.656

High

719750

CBLN4
Cerebellin-4

1

0

High-throughput

0.656

High

409280

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

15

Small-scale

0.647

High

719728

LIRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1

1

20

Small-scale

0.647

High

719713

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.646

High

719745

K1549
UPF0606 protein KIAA1549

3

0

High-throughput

0.638

High

719716

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

2

2

High-throughput

0.628

High

85957

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

17

High-throughput

0.618

High

627505

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

18

High-throughput

0.618

High

719727

LIRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2

1

20

Small-scale

0.618

High

719749

I17RB
Interleukin-17 receptor B

2

0

High-throughput

0.602

High

379899

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

15

High-throughput

0.575

High

380524

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

20

High-throughput

0.575

High

719718

MICB
MHC class I polypeptide-related sequence B

1

17

High-throughput

0.575

High

477155

ACM5
Muscarinic acetylcholine receptor M5

1

1

High-throughput

0.541

High

139182

UPK2
Uroplakin-2

1

2

High-throughput

0.536

High

191433

SIA8E
Alpha-2,8-sialyltransferase 8E

1

9

High-throughput

0.536

High

209374

SIA8C
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

1

9

High-throughput

0.536

High

341287

ECEL1
Endothelin-converting enzyme-like 1

1

4

High-throughput

0.536

High

506826

CFC1
Cryptic protein

1

1

High-throughput

0.536

High

547972

PSPC
Surfactant protein C

1

4

High-throughput

0.536

High

563271

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

636485

FUT3
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

1

1

High-throughput

0.536

High

719698

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

1

High-throughput

0.536

High

719704

DNSL1
Deoxyribonuclease-1-like 1

1

3

High-throughput

0.536

High

719710

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

2

High-throughput

0.536

High

719711

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

9

High-throughput

0.536

High

719721

ZACN
Ligand-gated cation channel ZACN

1

5

High-throughput

0.536

High

719722

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.536

High

719723

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

1

2

High-throughput

0.536

High

719724

BRID5
BRICHOS domain-containing protein 5

1

4

High-throughput

0.536

High

719726

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.536

High

719729

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

9

High-throughput

0.536

High

719731

AQP3
Aquaporin-3

1

1

High-throughput

0.536

High

719733

T106A
Transmembrane protein 106A

1

5

High-throughput

0.536

High

719734

ESPB1
Epididymal sperm-binding protein 1

1

1

High-throughput

0.536

High

719735

ASIC4
Acid-sensing ion channel 4

1

8

High-throughput

0.536

High

719741

CHST8
Carbohydrate sulfotransferase 8

1

3

High-throughput

0.536

High

719743

UD17
UDP-glucuronosyltransferase 1A7

1

5

High-throughput

0.536

High

719744

LY9
T-lymphocyte surface antigen Ly-9

1

7

High-throughput

0.536

High

719747

AT131
Endoplasmic reticulum transmembrane helix translocase

1

5

High-throughput

0.536

High

719748

ITM2C
Integral membrane protein 2C

1

5

High-throughput

0.536

High

719752

CC50A
Cell cycle control protein 50A

1

5

High-throughput

0.536

High

719753

SLAF8
SLAM family member 8

1

10

High-throughput

0.536

High

719756

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

12

High-throughput

0.536

High

719757

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

12

High-throughput

0.536

High

719762

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.536

High

624191

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

1

0

High-throughput

0.513

High

719714

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

719717

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

719732

SNX19
Sorting nexin-19

1

0

High-throughput

0.513

High

719736

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.513

High

719738

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.513

High

719742

GREM2
Gremlin-2

1

0

High-throughput

0.513

High

719746

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

719740

CST11
Cystatin-11

1

1

High-throughput

0.489

High

217874

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

692861

DPP4
Dipeptidyl peptidase 4

1

4

High-throughput

0.479

High

719705

PLTP
Phospholipid transfer protein

1

0

High-throughput

0.458

High

719751

GINM1
Glycoprotein integral membrane protein 1

1

0

High-throughput

0.458

High

538730

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

3

High-throughput

0.445

High

719709

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.445

High

719761

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.445

High

719715

TAZ
Tafazzin

1

1

High-throughput

0.437

High

719706

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.426

High

719699

KDM5C
Lysine-specific demethylase 5C

3

0

High-throughput

0.347

High

249281

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025