HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0043235 - receptor complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1382 Hs			1 1390
+	Hs
		435499 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Mm
		554979 EPHA4_MOUSE (562-1354): 0: 568: 20.48		MET_MOUSE (1-1381): 0: 1246: 89.57
+	Hs
		165142 INSR_HUMAN (1-1382): 0: 1530: 100.00		PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57
+	Hs
		411319 INSR_HUMAN (1-1382): 0: 1530: 100.00		RYK_HUMAN (1078-1334): 2.54e-59: 218: 39.47
+	Hs
		411275 INSR_HUMAN (1-1382): 0: 1530: 100.00		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		411268 INSR_HUMAN (1-1382): 0: 1530: 100.00		INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11
+	Hs
		411286 INSR_HUMAN (1-1382): 0: 1530: 100.00		INSRR_HUMAN (1056-1337): 6.24e-54: 209: 39.67
+	Hs
		411329 INSR_HUMAN (1-1382): 0: 1530: 100.00		CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77
+	Hs
		165145 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57
+	Hs
		435496 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		435522 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		INSRR_HUMAN (1056-1337): 6.24e-54: 209: 39.67
+	Hs
		435570 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77
+	Hs
		537719 INSRR_HUMAN (13-1341): 0: 1293: 51.12		UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90
+	Dm
		448230 INSR_DROME (30-1382): 0: 1002: 34.55		INSR_DROME (1084-1335): 8e-54: 209: 39.49
+	Hs
		665567 EPHB1_HUMAN (571-1318): 0: 569: 21.86		EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91
+	Mm
		872618 EPHA4_MOUSE (562-1354): 0: 568: 20.48		EPHB2_MOUSE (597-1389): 9.09e-157: 500: 19.53
+	Hs
		872511 EPHB1_HUMAN (571-1318): 0: 569: 21.86		EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72