HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: SDF2L (Q9HCN8)
Stromal cell-derived factor 2-like protein 1 (SDF2-like protein 1) (PWP1-interacting protein 8)
Gene: SDF2L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1382 Hs			1 221
+	Hs
		411482 INSR_HUMAN (1-1382): 0: 1530: 100.00		SDF2_HUMAN (26-221): 1.48e-84: 251: 65.15
+	Hs
		435770 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		SDF2L_HUMAN (1-221): 4.34e-95: 278: 100.00
+	Hs
		445879 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		SDF2L_HUMAN (1-221): 4.34e-95: 278: 100.00
+	Hs
		872580 EPHB4_HUMAN (622-1318): 2.16e-162: 515: 21.52		SDF2L_HUMAN (1-221): 4.34e-95: 278: 100.00
+	Hs
		445873 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		SDF2_HUMAN (26-221): 1.48e-84: 251: 65.15
+	Hs
		1336439 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		SDF2L_HUMAN (1-221): 4.34e-95: 278: 100.00
+	Hs
		1081611 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		SDF2L_HUMAN (1-221): 4.34e-95: 278: 100.00
+	Hs
		609551 FGFR3_HUMAN (1015-1287): 2.21e-62: 231: 40.78		SDF2L_HUMAN (1-221): 4.34e-95: 278: 100.00
+	Hs
		674533 UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09		SDF2L_HUMAN (1-221): 4.34e-95: 278: 100.00
+	Hs
		1081576 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		SDF2_HUMAN (26-221): 1.48e-84: 251: 65.15