Protein: K2C74
Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37)

Gene: K2C74, KRT74
Organism: Homo sapiens
Interactions: 40
UniProt ID: Q7RTS7

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0030280 - structural constituent of skin epidermis
GO:0031424 - keratinization
GO:0045095 - keratin filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475613

K1C19
Keratin, type I cytoskeletal 19

3

20

High-throughput

0.843

High

300665

KRT37
Keratin, type I cuticular Ha7

2

20

High-throughput

0.794

High

300395

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.783

High

300780

KRT38
Keratin, type I cuticular Ha8

2

20

High-throughput

0.783

High

476347

K1C16
Keratin, type I cytoskeletal 16

2

20

High-throughput

0.783

High

566280

K1C13
Keratin, type I cytoskeletal 13

2

20

High-throughput

0.783

High

618060

K1C15
Keratin, type I cytoskeletal 15

2

20

High-throughput

0.783

High

1146000

K1H1
Keratin, type I cuticular Ha1

2

20

High-throughput

0.783

High

1230329

K1C39
Keratin, type I cytoskeletal 39

2

20

High-throughput

0.783

High

1273937

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

1273938

K1C26
Keratin, type I cytoskeletal 26

2

20

High-throughput

0.783

High

1273939

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

1273941

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

300585

KRT36
Keratin, type I cuticular Ha6

1

20

High-throughput

0.621

High

1127653

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.621

High

1178739

K1C24
Keratin, type I cytoskeletal 24

1

20

High-throughput

0.621

High

1230103

K1C40
Keratin, type I cytoskeletal 40

1

20

High-throughput

0.621

High

385292

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.618

High

436916

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.618

High

437236

K2C8
Keratin, type II cytoskeletal 8

1

19

High-throughput

0.618

High

566410

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.618

High

1273946

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

965476

LMO4
LIM domain transcription factor LMO4

2

7

High-throughput

0.553

High

563980

CFTR
Cystic fibrosis transmembrane conductance regulator

1

17

High-throughput

0.536

High

293921

CD123
Translation initiation factor eIF2 assembly protein

1

10

High-throughput

0.479

High

323455

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

324954

HEXI1
Protein HEXIM1

1

20

High-throughput

0.479

High

1140095

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

15

High-throughput

0.479

High

1254394

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1273942

ACE2
Angiotensin-converting enzyme 2

1

7

High-throughput

0.479

High

1273943

DDX24
ATP-dependent RNA helicase DDX24

1

20

High-throughput

0.479

High

1273944

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

1273945

MYO10
Unconventional myosin-X

1

4

Small-scale

0.479

High

1273947

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1273948

ALK
ALK tyrosine kinase receptor

1

3

Small-scale

0.479

High

1118726

KLF5
Krueppel-like factor 5

1

2

High-throughput

0.457

High

244985

KATIP
Katanin-interacting protein

1

1

High-throughput

0.445

High

862253

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.445

High

1063799

LG3BP
Galectin-3-binding protein

1

9

High-throughput

0.445

High

1273940

SULF2
Extracellular sulfatase Sulf-2

1

11

High-throughput

0.407

High


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Last updated: 11Aug2025