HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: RACK1 (P63244)
Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Gene: RACK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0030425 - dendrite GO:0042803 - protein homodimerization activity GO:0043025 - neuronal cell body GO:0043547 - positive regulation of GTPase activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 317
+	Hs
		411686 NTRK1_HUMAN (1-796): 0: 624: 100.00		WDR5_HUMAN (3-219): 8.82e-62: 201: 26.70
+	Hs
		411528 NTRK1_HUMAN (1-796): 0: 624: 100.00		LIS1_HUMAN (144-316): 1.51e-45: 160: 23.43
+	Hs
		412570 NTRK1_HUMAN (1-796): 0: 624: 100.00		TBL1R_HUMAN (187-316): 1.26e-19: 90.8: 15.75
+	Hs
		650078 FGFR3_HUMAN (168-794): 3.36e-157: 479: 25.83		LIS1_HUMAN (144-316): 1.51e-45: 160: 23.43
+	Hs
		465480 IGF1R_HUMAN (493-777): 7e-71: 255: 42.61		RACK1_HUMAN (1-317): 4.84e-109: 321: 100.00
+	Hs
		439699 INSR_HUMAN (493-777): 3.01e-68: 248: 42.62		RACK1_HUMAN (1-317): 4.84e-109: 321: 100.00
+	Hs
		993023 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		RACK1_HUMAN (1-317): 4.84e-109: 321: 100.00
+	Hs
		711866 LTK_HUMAN (502-790): 3.11e-60: 221: 41.64		RACK1_HUMAN (1-317): 4.84e-109: 321: 100.00
+	Hs
		179603 MUSK_HUMAN (171-374): 3.43e-13: 75.5: 19.07		RACK1_HUMAN (1-317): 4.84e-109: 321: 100.00
+	Hs
		1063004 DDR1_HUMAN (507-778): 1.78e-67: 242: 45.49		SNR40_HUMAN (226-317): 2.69e-15: 77.4: 22.34
+	Hs
		1415099 ALK_HUMAN (505-790): 8.76e-63: 231: 42.07		KTNB1_HUMAN (10-213): 1.19e-17: 85.5: 28.29