HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PLCH1 (Q4KWH8)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)
Gene: PLCH1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0051209 - release of sequestered calcium ion into cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 1693
+	Hs
		433798 LYN_HUMAN (1-509): 0: 582: 62.72		PLCH1_HUMAN (1-1693): 0: 2265: 100.00
+	Hs
		434024 LYN_HUMAN (1-509): 0: 582: 62.72		PLCB1_HUMAN (21-1008): 0: 603: 16.71
+	Hs
		846042 SRMS_HUMAN (29-502): 3.04e-160: 465: 41.34		PLCD1_HUMAN (1-857): 0: 666: 28.06
+	Hs
		412000 FYN_HUMAN (30-507): 0: 586: 59.01		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Hs
		522758 SRC_HUMAN (20-507): 0: 586: 55.00		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Mm
		763400 FYN_MOUSE (30-507): 0: 586: 58.80		PLCG2_MOUSE (546-858): 5.33e-77: 283: 31.10
+	Mm
		639456 LYN_MOUSE (1-509): 0: 585: 62.33		PLCG2_MOUSE (546-858): 5.33e-77: 283: 31.10
+	Hs
		411992 FYN_HUMAN (30-507): 0: 586: 59.01		PLCG2_HUMAN (592-858): 1.91e-75: 278: 35.38
+	Hs
		433564 LYN_HUMAN (1-509): 0: 582: 62.72		PLCG2_HUMAN (592-858): 1.91e-75: 278: 35.38
+	Hs
		562634 BLK_HUMAN (1-509): 0: 557: 59.35		PLCG2_HUMAN (592-858): 1.91e-75: 278: 35.38
+	Mm
		557351 BLK_MOUSE (1-509): 0: 550: 59.80		PLCG2_MOUSE (546-858): 5.33e-77: 283: 31.10
+	Hs
		580990 ITK_HUMAN (7-500): 1.08e-177: 515: 33.33		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Hs
		337341 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Hs
		580953 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		PLCG1_HUMAN (547-921): 9.5e-78: 286: 29.82
+	Mm
		623690 TEC_MOUSE (7-503): 8.14e-166: 485: 33.59		PLCG1_MOUSE (430-941): 1.03e-81: 298: 24.76
+	Mm
		729760 BTK_MOUSE (7-505): 6.84e-168: 491: 32.89		PLCG2_MOUSE (546-858): 5.33e-77: 283: 31.10
+	Hs
		562642 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		PLCG2_HUMAN (592-858): 1.91e-75: 278: 35.38