HitPredict

Interactor 1: VIME (P08670)
Vimentin
Gene: VIM

Interactor 2: DESM (P17661)
Desmin
Gene: DES

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.934

Property	Details
Experiments	28514442, 32296183, 33961781, 27107012, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, validated two hybrid, barcode fusion genetics two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization GO:0045111 - intermediate filament cytoskeleton and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 466 Hs			1 470
+	Hs
		408979 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		VIME_HUMAN (28-469): 1.16e-150: 439: 62.19
+	Hs
		409022 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		PERI_HUMAN (12-470): 2.13e-134: 397: 59.14
+	Hs
		569056 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		PERI_HUMAN (12-470): 2.13e-134: 397: 59.14
+	Hs
		408991 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		GFAP_HUMAN (89-470): 3.61e-131: 387: 61.62
+	Hs
		535322 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		GFAP_HUMAN (89-470): 3.61e-131: 387: 61.62
+	Hs
		569045 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		DESM_HUMAN (1-470): 3.6e-109: 333: 100.00
+	Hs
		409089 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		AINX_HUMAN (12-427): 1.09e-95: 299: 49.76
+	Hs
		569086 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		AINX_HUMAN (12-427): 1.09e-95: 299: 49.76
+	Hs
		422142 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		NFL_HUMAN (87-418): 9.76e-89: 282: 53.89
+	Hs
		569099 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		K2C73_HUMAN (7-419): 7.28e-89: 282: 30.19
+	Hs
		318775 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		K2C75_HUMAN (9-427): 1.91e-82: 266: 33.33
+	Hs
		408975 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		NFM_HUMAN (100-417): 8.9e-78: 262: 46.42
+	Hs
		422140 GFAP_HUMAN (80-465): 2.56e-132: 390: 61.40		NFL_HUMAN (87-418): 9.76e-89: 282: 53.89
+	Hs
		422344 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		NFM_HUMAN (100-417): 8.9e-78: 262: 46.42
+	Hs
		409072 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		K1H2_HUMAN (29-425): 1.91e-74: 242: 26.50
+	Hs
		409184 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		KRT35_HUMAN (9-422): 1.39e-72: 238: 27.10
+	Hs
		280770 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		KRT36_HUMAN (8-470): 3.53e-69: 229: 26.32
+	Hs
		280845 K2C8_HUMAN (79-461): 3.38e-139: 410: 35.51		KRT37_HUMAN (5-422): 3.78e-65: 218: 28.50
+	Hs
		280850 DESM_HUMAN (9-465): 6.68e-138: 406: 62.20		KRT37_HUMAN (5-422): 3.78e-65: 218: 28.50