HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: HAVR2 (Q8TDQ0)
Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
Gene: HAVCR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.588

Property	Details
Experiments	22863785, 26492563
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001772 - immunological synapse GO:0045087 - innate immune response
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 301
+	Hs
		412276 FYN_HUMAN (30-507): 0: 586: 59.01		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		412298 FYN_HUMAN (30-507): 0: 586: 59.01		HAVR1_HUMAN (10-133): 2.47e-51: 174: 40.95