HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031410 - cytoplasmic vesicle GO:0045666 - positive regulation of neuron differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 986
+	Hs
		541313 FGFR1_HUMAN (1-822): 0: 858: 100.00		VAV_HUMAN (171-727): 5.21e-91: 310: 15.11
+	Hs
		541509 FGFR1_HUMAN (1-822): 0: 858: 100.00		ITSN1_HUMAN (222-600): 2.11e-69: 255: 22.73
+	Hs
		541723 FGFR1_HUMAN (1-822): 0: 858: 100.00		ITSN2_HUMAN (222-599): 2.89e-66: 245: 22.90
+	Hs
		541632 FGFR1_HUMAN (1-822): 0: 858: 100.00		ARHGQ_HUMAN (203-617): 1.56e-49: 191: 18.26
+	Hs
		641273 FGFR2_HUMAN (1-812): 0: 794: 71.50		ITSN2_HUMAN (222-599): 2.89e-66: 245: 22.90
+	Hs
		913632 EPHA4_HUMAN (3-783): 0: 615: 19.44		VAV2_HUMAN (132-799): 1.51e-101: 340: 14.77
+	Mm
		1190242 EPHB1_MOUSE (4-798): 0: 637: 17.57		Q3UHH6_MOUSE (14-814): 1.37e-88: 313: 15.96
+	Rn
		73342 B2B9B0_RAT (4-819): 0: 622: 17.83		D3ZWV8_RAT (17-814): 2.9e-87: 309: 16.02
+	Hs
		648527 FGFR4_HUMAN (31-813): 0: 660: 55.33		ITSN1_HUMAN (222-600): 2.11e-69: 255: 22.73
+	Hs
		648704 FGFR4_HUMAN (31-813): 0: 660: 55.33		ITSN2_HUMAN (222-599): 2.89e-66: 245: 22.90
+	Hs
		299548 EPHA7_HUMAN (3-783): 0: 624: 19.40		TRIO_HUMAN (224-976): 3.48e-75: 273: 12.76
+	Hs
		648482 FGFR4_HUMAN (31-813): 0: 660: 55.33		FGD1_HUMAN (233-610): 5.53e-63: 233: 19.14
+	Hs
		710840 EPHB2_HUMAN (4-819): 0: 637: 18.07		ITSN1_HUMAN (222-600): 2.11e-69: 255: 22.73
+	Mm
		1041423 EPHA2_MOUSE (3-819): 0: 573: 18.96		Q3UHH6_MOUSE (14-814): 1.37e-88: 313: 15.96
+	Hs
		710295 EPHA2_HUMAN (3-819): 0: 583: 18.48		ARHGG_HUMAN (114-623): 5.47e-83: 285: 18.35
+	Hs
		299518 EPHA2_HUMAN (3-819): 0: 583: 18.48		TRIO_HUMAN (224-976): 3.48e-75: 273: 12.76
+	Hs
		710527 EPHA2_HUMAN (3-819): 0: 583: 18.48		ITSN2_HUMAN (222-599): 2.89e-66: 245: 22.90
+	Mm
		581987 NTRK2_MOUSE (110-762): 1.03e-161: 492: 23.71		TIAM1_MOUSE (14-814): 1.97e-87: 310: 15.96
+	Rn
		93140 NTRK2_RAT (110-762): 2.41e-161: 491: 23.85		D3ZWV8_RAT (17-814): 2.9e-87: 309: 16.02
+	Hs
		299550 NTRK3_HUMAN (163-762): 7.64e-160: 488: 25.08		TRIO_HUMAN (224-976): 3.48e-75: 273: 12.76