Protein: SOS1
Son of sevenless homolog 1 (SOS-1)

Gene: SOS1
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q07889

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0001942 - hair follicle development
GO:0002931 - response to ischemia
GO:0003209 - cardiac atrium morphogenesis
GO:0003344 - pericardium morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987577

GRB2
Growth factor receptor-bound protein 2

64

20

Small-scale

0.997

High

374546

RASH
GTPase HRas

10

20

Small-scale

0.972

High

593974

NCK1
SH2/SH3 adapter protein NCK1

8

20

Small-scale

0.971

High

1060677

ITSN1
Intersectin-1

8

19

Small-scale

0.971

High

855598

CRK
Adapter molecule crk

9

20

Small-scale

0.970

High

619037

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

4

7

Small-scale

0.906

High

855855

CRKL
Crk-like protein

4

20

High-throughput

0.881

High

1060674

EPS8
Epidermal growth factor receptor kinase substrate 8

4

20

Small-scale

0.873

High

1060697

ITSN2
Intersectin-2

2

16

High-throughput

0.791

High

440511

FYN
Tyrosine-protein kinase Fyn

2

20

Small-scale

0.768

High

473405

HCK
Tyrosine-protein kinase HCK

2

20

Small-scale

0.768

High

363175

EGFR
Epidermal growth factor receptor

15

20

Small-scale

0.759

High

711325

SHC1
SHC-transforming protein 1

13

20

Small-scale

0.756

High

540004

BCR
Breakpoint cluster region protein

2

15

Small-scale

0.754

High

1060706

CD2AP
CD2-associated protein

2

20

Small-scale

0.754

High

1060679

SPD2A
SH3 and PX domain-containing protein 2A

1

20

Small-scale

0.747

High

1060683

ABI1
Abl interactor 1

1

14

Small-scale

0.747

High

222064

NCK2
Cytoplasmic protein NCK2

2

20

Small-scale

0.737

High

1005354

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

2

Small-scale

0.724

High

1060687

FRS2
Fibroblast growth factor receptor substrate 2

5

2

Small-scale

0.702

High

1060676

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

12

High-throughput

0.698

High

1053649

PTN11
Tyrosine-protein phosphatase non-receptor type 11

4

6

Small-scale

0.683

High

1060707

SNX9
Sorting nexin-9

1

3

Small-scale

0.665

High

138483

BIN1
Myc box-dependent-interacting protein 1

3

9

Small-scale

0.641

High

362262

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.618

High

373900

RASN
GTPase NRas

1

20

Small-scale

0.618

High

375451

RASK
GTPase KRas

1

20

Small-scale

0.618

High

557252

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.618

High

988312

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.618

High

1060675

GRAP
GRB2-related adapter protein

1

20

Small-scale

0.618

High

1060680

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.618

High

1060686

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

20

Small-scale

0.618

High

1060692

RIT2
GTP-binding protein Rit2

1

20

Small-scale

0.618

High

1060693

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.618

High

1060696

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

20

Small-scale

0.618

High

943757

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

18

High-throughput

0.606

High

1060704

CSN3
COP9 signalosome complex subunit 3

1

1

Small-scale

0.586

High

590276

MUC1
Mucin-1

2

2

Small-scale

0.584

High

1060685

DP13B
DCC-interacting protein 13-beta

1

1

Small-scale

0.575

High

239421

3BP5
SH3 domain-binding protein 5

2

0

High-throughput

0.565

High

635521

NEBU
Nebulin

1

18

Small-scale

0.554

High

1024525

VIGLN
Vigilin

1

2

High-throughput

0.541

High

691719

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.536

High

914248

EFNA4
Ephrin-A4

1

1

High-throughput

0.536

High

440044

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.527

High

1060684

TXND5
Thioredoxin domain-containing protein 5

2

5

High-throughput

0.521

High

181620

CETN3
Centrin-3

1

1

High-throughput

0.515

High

1060703

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

9

Small-scale

0.515

High

867069

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

1060681

NOSTN
Nostrin

1

15

Small-scale

0.501

High

1060700

GGA1
ADP-ribosylation factor-binding protein GGA1

1

1

High-throughput

0.501

High

1060702

TNIK
TRAF2 and NCK-interacting protein kinase

1

7

High-throughput

0.481

High

456703

ANXA2
Annexin A2

1

0

Small-scale

0.480

High

138083

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.479

High

221121

SPY2
Protein sprouty homolog 2

1

5

Small-scale

0.479

High

221415

SPY3
Protein sprouty homolog 3

1

5

Small-scale

0.479

High

411801

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

456142

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

6

Small-scale

0.479

High

468297

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

472048

MET
Hepatocyte growth factor receptor

1

18

Small-scale

0.479

High

622595

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

Small-scale

0.479

High

648148

NDKB
Nucleoside diphosphate kinase B

1

3

High-throughput

0.479

High

651296

CBL
E3 ubiquitin-protein ligase CBL

1

8

Small-scale

0.479

High

699712

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

8

High-throughput

0.479

High

711111

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

7

Small-scale

0.479

High

767179

MERL
Merlin

1

5

Small-scale

0.479

High

914194

EFNA3
Ephrin-A3

1

1

High-throughput

0.479

High

1060678

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

3

High-throughput

0.479

High

1060682

SRRM1
Serine/arginine repetitive matrix protein 1

1

7

High-throughput

0.479

High

1060688

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

1060690

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.479

High

1060691

SNX18
Sorting nexin-18

1

3

Small-scale

0.479

High

1060698

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

11

High-throughput

0.479

High

1060699

CSN7A
COP9 signalosome complex subunit 7a

1

2

Small-scale

0.479

High

595411

H15
Histone H1.5

1

1

High-throughput

0.470

High

1060694

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

12

High-throughput

0.457

High

463947

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.445

High

1050976

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.445

High

1060705

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

1060695

BRD8
Bromodomain-containing protein 8

1

4

High-throughput

0.437

High

1060689

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

1060701

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025