HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	25416956, 34079125
Identification Methods	two hybrid, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 669
+	Hs
		433974 LYN_HUMAN (1-509): 0: 582: 62.72		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		411908 LCK_HUMAN (1-509): 0: 661: 100.00		MRCKB_HUMAN (197-560): 2.09e-10: 66.2: 13.44
+	Hs
		411758 LCK_HUMAN (1-509): 0: 661: 100.00		MRCKA_HUMAN (328-609): 6.79e-09: 61.6: 11.68
+	Hs
		61846 HCK_HUMAN (1-509): 0: 602: 65.04		CC88B_HUMAN (60-668): 4.55e-16: 84.7: 12.48
+	Hs
		433781 LYN_HUMAN (1-509): 0: 582: 62.72		ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88
+	Hs
		523231 SRC_HUMAN (20-507): 0: 586: 55.00		MYH4_HUMAN (261-669): 1.55e-12: 73.1: 12.32
+	Hs
		412287 FYN_HUMAN (30-507): 0: 586: 59.01		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		434101 LYN_HUMAN (1-509): 0: 582: 62.72		MRCKB_HUMAN (197-560): 2.09e-10: 66.2: 13.44
+	Hs
		433818 LYN_HUMAN (1-509): 0: 582: 62.72		MRCKA_HUMAN (328-609): 6.79e-09: 61.6: 11.68
+	Hs
		337577 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		EP15R_HUMAN (483-668): 6.69e-11: 67.8: 12.90