HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PHAG1 (Q9NWQ8)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)
Gene: PAG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

Property	Details
Experiments	10790433, 18070987
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	PAG~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction GO:0042169 - SH2 domain binding GO:0045121 - membrane raft
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 432
+	Mm
		411925 LCK_MOUSE (1-509): 0: 657: 96.86		PHAG1_MOUSE (1-432): 0: 759: 78.21
+	Mm
		763390 FYN_MOUSE (30-507): 0: 586: 58.80		PHAG1_MOUSE (1-432): 0: 759: 78.21
+	Mm
		639443 LYN_MOUSE (1-509): 0: 585: 62.33		PHAG1_MOUSE (1-432): 0: 759: 78.21
+	Hs
		412375 FYN_HUMAN (30-507): 0: 586: 59.01		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Hs
		523175 SRC_HUMAN (20-507): 0: 586: 55.00		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Hs
		434038 LYN_HUMAN (1-509): 0: 582: 62.72		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Hs
		789135 FRK_HUMAN (50-503): 0: 530: 48.20		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Mm
		976830 ITK_MOUSE (6-500): 4.47e-177: 513: 33.53		PHAG1_MOUSE (1-432): 0: 759: 78.21
+	Hs
		337571 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		PHAG1_HUMAN (1-432): 0: 755: 100.00
+	Rn
		693647 CSK_RAT (58-500): 1.36e-174: 500: 39.04		PHAG1_RAT (1-432): 0: 740: 79.13