Protein: BTNL2
Butyrophilin-like protein 2 (BTL-II)

Gene: BTNL2
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q9UIR0

Gene Ontology (top 5):
GO:0001817 - regulation of cytokine production
GO:0005102 - signaling receptor binding
GO:0005886 - plasma membrane
GO:0009897 - external side of plasma membrane
GO:0032743 - positive regulation of interleukin-2 production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161102

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

7

High-throughput

0.691

High

175448

PLXB2
Plexin-B2

1

15

High-throughput

0.691

High

282869

CRLF1
Cytokine receptor-like factor 1

1

20

High-throughput

0.691

High

287626

LRP6
Low-density lipoprotein receptor-related protein 6

1

1

High-throughput

0.691

High

296386

ATRN
Attractin

1

9

High-throughput

0.691

High

320907

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

12

High-throughput

0.691

High

363993

EGFR
Epidermal growth factor receptor

1

19

High-throughput

0.691

High

366295

FA10
Coagulation factor X

1

5

High-throughput

0.691

High

380376

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

11

High-throughput

0.691

High

380667

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

13

High-throughput

0.691

High

409530

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

6

High-throughput

0.691

High

439874

INSR
Insulin receptor

1

20

High-throughput

0.691

High

448077

ITAV
Integrin alpha-V

1

11

High-throughput

0.691

High

472141

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.691

High

473732

ITA5
Integrin alpha-5

1

11

High-throughput

0.691

High

521043

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

6

High-throughput

0.691

High

552093

ADT1
ADP/ATP translocase 1

1

4

High-throughput

0.691

High

568097

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

6

High-throughput

0.691

High

580851

PVR
Poliovirus receptor

1

17

High-throughput

0.691

High

603819

ITA2
Integrin alpha-2

1

12

High-throughput

0.691

High

612124

ITB5
Integrin beta-5

1

5

High-throughput

0.691

High

640322

EPHA1
Ephrin type-A receptor 1

1

12

High-throughput

0.691

High

655024

ITA6
Integrin alpha-6

1

11

High-throughput

0.691

High

719755

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

6

High-throughput

0.691

High

731941

L1CAM
Neural cell adhesion molecule L1

1

15

High-throughput

0.691

High

788553

SCNNA
Epithelial sodium channel subunit alpha

1

1

High-throughput

0.691

High

907948

PLXA3
Plexin-A3

1

15

High-throughput

0.691

High

1009170

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

15

High-throughput

0.691

High

1034372

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.691

High

1037055

DSC2
Desmocollin-2

1

7

High-throughput

0.691

High

1049208

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.691

High

1055373

APLP2
Amyloid beta precursor like protein 2

1

7

High-throughput

0.691

High

1064082

MFGM
Lactadherin

1

6

High-throughput

0.691

High

1098339

SEM3B
Semaphorin-3B

1

4

High-throughput

0.691

High

1101789

PTK7
Inactive tyrosine-protein kinase 7

1

20

High-throughput

0.691

High

1105790

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

7

High-throughput

0.691

High

1116747

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

11

High-throughput

0.691

High

1144682

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

11

High-throughput

0.691

High

1213218

AGRF1
Adhesion G-protein coupled receptor F1

1

4

High-throughput

0.691

High

1242472

CNNM4
Metal transporter CNNM4

1

3

High-throughput

0.691

High

1310187

AGRA3
Adhesion G protein-coupled receptor A3

1

16

High-throughput

0.691

High

1336111

KREM2
Kremen protein 2

1

5

High-throughput

0.691

High

1337082

CNNM3
Metal transporter CNNM3

1

3

High-throughput

0.691

High

1339615

NLGN2
Neuroligin-2

1

2

High-throughput

0.691

High

1366682

SORL
Sortilin-related receptor

1

2

High-throughput

0.691

High

1366846

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

9

High-throughput

0.691

High

1369570

SEM4D
Semaphorin-4D

1

4

High-throughput

0.691

High

1376967

HMR1
Major histocompatibility complex class I-related protein 1

1

7

High-throughput

0.691

High

1419503

CNTP3
Contactin-associated protein-like 3

1

11

High-throughput

0.691

High

1429275

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

7

High-throughput

0.691

High

1432921

SEM6B
Semaphorin-6B

1

4

High-throughput

0.691

High

1447208

NECT3
Nectin-3

1

19

High-throughput

0.691

High

1449615

SEM4G
Semaphorin-4G

1

5

High-throughput

0.691

High

1452232

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

1

2

High-throughput

0.691

High

1452763

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

4

High-throughput

0.691

High

1454620

TUTLA
Protein turtle homolog A

1

18

High-throughput

0.691

High

1460476

PLXA1
Plexin-A1

1

13

High-throughput

0.691

High

1460478

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

7

High-throughput

0.691

High

1460479

JAG2
Protein jagged-2

1

5

High-throughput

0.691

High

1460482

ST14
Suppressor of tumorigenicity 14 protein

1

9

High-throughput

0.691

High

1460483

AGRG1
Adhesion G-protein coupled receptor G1

1

3

High-throughput

0.691

High

467861

BGLR
Beta-glucuronidase

1

0

High-throughput

0.656

High

571256

PERF
Perforin-1

1

0

High-throughput

0.656

High

1089133

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.656

High

63056

POTEF
POTE ankyrin domain family member F

1

2

High-throughput

0.618

High

160845

TOR1B
Torsin-1B

1

1

High-throughput

0.618

High

193727

TPSN
Tapasin

1

10

High-throughput

0.618

High

276228

LRRN2
Leucine-rich repeat neuronal protein 2

1

15

High-throughput

0.618

High

324059

CSTN1
Calsyntenin-1

1

8

High-throughput

0.618

High

562769

BMP1
Bone morphogenetic protein 1

1

3

High-throughput

0.618

High

1006233

CNTP1
Contactin-associated protein 1

1

12

High-throughput

0.618

High

1022497

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.618

High

1281704

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

11

High-throughput

0.618

High

1281726

GALT5
Polypeptide N-acetylgalactosaminyltransferase 5

1

2

High-throughput

0.618

High

1292150

ANR46
Ankyrin repeat domain-containing protein 46

1

11

High-throughput

0.618

High

1307721

CILP2
Cartilage intermediate layer protein 2

1

5

High-throughput

0.618

High

1335824

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

2

High-throughput

0.618

High

1356813

NEUFC
Neuferricin

1

1

High-throughput

0.618

High

1402430

HPLN3
Hyaluronan and proteoglycan link protein 3

1

7

High-throughput

0.618

High

1452024

TOR4A
Torsin-4A

1

1

High-throughput

0.618

High

1454451

FPRP
Prostaglandin F2 receptor negative regulator

1

19

High-throughput

0.618

High

1131495

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.578

High

1251912

THSD4
Thrombospondin type-1 domain-containing protein 4

1

0

High-throughput

0.578

High

380599

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

14

High-throughput

0.575

High

61151

T131L
Transmembrane protein 131-like

1

3

High-throughput

0.536

High

230851

EXTL3
Exostosin-like 3

1

1

High-throughput

0.536

High

244506

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

1

High-throughput

0.536

High

277045

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

1

High-throughput

0.536

High

535655

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.536

High

1120652

DAG1
Dystroglycan 1

1

6

High-throughput

0.536

High

1126053

GAS6
Growth arrest-specific protein 6

1

16

High-throughput

0.536

High

1159185

SGCB
Beta-sarcoglycan

1

1

High-throughput

0.536

High

1218874

GP107
Protein GPR107

1

2

High-throughput

0.536

High

1248244

CSPG4
Chondroitin sulfate proteoglycan 4

1

7

High-throughput

0.536

High

1356842

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

2

High-throughput

0.536

High

1450326

CC50A
Cell cycle control protein 50A

1

1

High-throughput

0.536

High

1460010

CEIP2
Cell surface hyaluronidase CEMIP2

1

2

High-throughput

0.536

High

1460481

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.536

High

1399254

CNT3B
Contactin-associated protein-like 3B

1

12

High-throughput

0.514

High

354189

CLPT1
Putative lipid scramblase CLPTM1

1

0

High-throughput

0.513

High

771684

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.513

High

1175851

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

1274073

OTOAN
Otoancorin

1

0

High-throughput

0.513

High

1309813

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

0

High-throughput

0.513

High

1356280

ABHD3
Phospholipase ABHD3

1

0

High-throughput

0.513

High

1382896

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.513

High

350751

NOE2
Noelin-2

1

2

High-throughput

0.489

High

462931

LAMB1
Laminin subunit beta-1

1

14

High-throughput

0.489

High

617357

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

5

High-throughput

0.489

High

618211

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

3

High-throughput

0.489

High

937449

LAMB2
Laminin subunit beta-2

1

15

High-throughput

0.489

High

982000

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.489

High

1034844

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.489

High

1117027

LAMB3
Laminin subunit beta-3

1

14

High-throughput

0.489

High

1164362

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

1

High-throughput

0.489

High

1192001

TBB8
Tubulin beta-8 chain

1

9

High-throughput

0.489

High

1225417

METRL
Meteorin-like protein

1

1

High-throughput

0.489

High

1237894

MYORG
Myogenesis-regulating glycosidase

1

1

High-throughput

0.489

High

1280085

FRMD5
FERM domain-containing protein 5

1

11

High-throughput

0.489

High

1333857

TTC13
Tetratricopeptide repeat protein 13

1

2

High-throughput

0.489

High

1335599

CHSTE
Carbohydrate sulfotransferase 14

1

1

High-throughput

0.489

High

1352550

GPX8
Probable glutathione peroxidase 8

1

1

High-throughput

0.489

High

1364169

TM131
Transmembrane protein 131

1

6

High-throughput

0.489

High

1372154

EXT2
Exostosin-2

1

1

High-throughput

0.489

High

1408181

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

5

High-throughput

0.489

High

1415051

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

2

High-throughput

0.489

High

1415790

T106C
Transmembrane protein 106C

1

2

High-throughput

0.489

High

1420152

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

2

High-throughput

0.489

High

1448144

CHSTC
Carbohydrate sulfotransferase 12

1

1

High-throughput

0.489

High

1452795

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

3

High-throughput

0.489

High

1459700

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.489

High

1460477

METRN
Meteorin

1

1

High-throughput

0.489

High

1460480

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.489

High

1386622

OPTN
Optineurin

1

9

High-throughput

0.470

High

872855

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.437

High

212614

GPAA1
GPI-anchor transamidase component GPAA1

1

0

High-throughput

0.279

Low

251127

B4GT3
Beta-1,4-galactosyltransferase 3

1

0

High-throughput

0.279

Low

885518

MA2A2
Alpha-mannosidase 2x

1

0

High-throughput

0.279

Low

1028112

B4GN1
Beta-1,4 N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

1143696

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.279

Low

1204907

MKS3
Meckelin

1

0

High-throughput

0.279

Low

1228412

SE1L3
Protein sel-1 homolog 3

1

0

High-throughput

0.279

Low

1248933

ARSK
Arylsulfatase K

1

0

High-throughput

0.279

Low

1258709

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

1325553

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

0

High-throughput

0.279

Low

1332779

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

1333640

SUMF1
Formylglycine-generating enzyme

1

0

High-throughput

0.279

Low

1361375

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

1361985

TM158
Transmembrane protein 158

1

0

High-throughput

0.279

Low

1380560

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

1396603

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.279

Low

1398254

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

0

High-throughput

0.279

Low

1408250

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

1452390

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

1454509

CHPF2
Chondroitin sulfate glucuronyltransferase

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025