HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: FARP1 (Q9Y4F1)
FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)
Gene: FARP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 1045
+	Hs
		434097 LYN_HUMAN (1-509): 0: 582: 62.72		FARP1_HUMAN (1-1045): 0: 848: 100.00
+	Hs
		299230 LYN_HUMAN (1-509): 0: 582: 62.72		FARP2_HUMAN (1-1040): 0: 780: 53.19
+	Hs
		411855 LCK_HUMAN (1-509): 0: 661: 100.00		E41L1_HUMAN (20-550): 6.05e-122: 396: 29.16
+	Hs
		411867 LCK_HUMAN (1-509): 0: 661: 100.00		E41L5_HUMAN (7-551): 1.15e-122: 394: 26.72
+	Hs
		411899 LCK_HUMAN (1-509): 0: 661: 100.00		E41L3_HUMAN (35-538): 1.5e-115: 384: 30.87
+	Hs
		411673 LCK_HUMAN (1-509): 0: 661: 100.00		FGD1_HUMAN (317-1040): 1.54e-101: 343: 18.94
+	Hs
		412035 FYN_HUMAN (30-507): 0: 586: 59.01		PTN4_HUMAN (18-517): 1.38e-123: 402: 32.68
+	Hs
		434008 LYN_HUMAN (1-509): 0: 582: 62.72		E41L1_HUMAN (20-550): 6.05e-122: 396: 29.16
+	Hs
		434020 LYN_HUMAN (1-509): 0: 582: 62.72		E41L5_HUMAN (7-551): 1.15e-122: 394: 26.72
+	Hs
		412416 FYN_HUMAN (30-507): 0: 586: 59.01		E41L3_HUMAN (35-538): 1.5e-115: 384: 30.87
+	Hs
		523221 SRC_HUMAN (20-507): 0: 586: 55.00		E41L3_HUMAN (35-538): 1.5e-115: 384: 30.87
+	Hs
		204599 LYN_HUMAN (1-509): 0: 582: 62.72		E41L2_HUMAN (3-549): 7.69e-117: 386: 29.58
+	Hs
		434091 LYN_HUMAN (1-509): 0: 582: 62.72		E41L3_HUMAN (35-538): 1.5e-115: 384: 30.87
+	Hs
		433541 LYN_HUMAN (1-509): 0: 582: 62.72		EPB41_HUMAN (3-547): 3.71e-115: 378: 29.21
+	Hs
		434004 LYN_HUMAN (1-509): 0: 582: 62.72		E41LB_HUMAN (26-547): 2.8e-110: 365: 25.52
+	Hs
		433240 YES_HUMAN (26-507): 0: 581: 58.06		EZRI_HUMAN (37-558): 4.42e-103: 337: 20.07
+	Hs
		337358 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		PTN4_HUMAN (18-517): 1.38e-123: 402: 32.68
+	Hs
		523042 SRC_HUMAN (20-507): 0: 586: 55.00		FRMD5_HUMAN (25-490): 8.26e-100: 328: 28.60
+	Hs
		433618 LYN_HUMAN (1-509): 0: 582: 62.72		RADI_HUMAN (37-582): 1.65e-99: 327: 19.25
+	Hs
		337601 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		E41L3_HUMAN (35-538): 1.5e-115: 384: 30.87